摘要
N^(6)-甲基腺嘌呤(N^(6)-methyladenosine,m^(6)A)修饰是RNA分子的转录后变化,m^(6)A最早是上世纪70年代在细胞mRNA上发现的,但直到全基因组m^(6)A定位方法发展后才被广泛研究。近年来m^(6)A在调节mRNA中的作用及其在各种细胞类型中的功能及其重要性已经得到了证实,m^(6)A调控多种生理过程中基因表达的机制研究也越来越多。此综述总结了最近一些关于m^(6)A修饰在免疫反应中的作用的研究进展,讨论了m^(6)A修饰在调节先天和适应性免疫反应以及免疫系统发育中的功能。
N^(6)-methyladenosine(m^(6)A)modification is a post-transcriptional change of RNA molecule.m^(6)A was first discovered in cell mRNA in 1970s,but the extensive investigation on m^(6)A modification did not begin until the genome-wide m^(6)A localization method was developed.The role of m^(6)A in regulating mRNA and its functional importance in various cell types have been verified in many studies,and the mechanism of m^(6)A in regulating gene expression in a variety of physiological processes has been increasingly studied recently.In this review,we summarized recent advances in m^(6)A modification in immune response,and discussed the regulatory role of m^(6)A modification in innate and adaptive immune responses,and immune system development.
作者
陈艺苒
范斌
CHEN Yiran;FAN Bin(Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,200437,China)
出处
《医学分子生物学杂志》
CAS
2022年第3期252-256,共5页
Journal of Medical Molecular Biology
基金
国家自然科学基金(No.82074302)。
