摘要
目的分析血清神经导向因子4(netrin⁃4)、玻连蛋白(Vitronectin)与急性缺血性脑卒中(AIS)患者神经功能、颈动脉内膜厚度的关系。方法选择2019年5月至2020年5月郴州市第一人民医院收治的116例AIS患者作为研究组,同期进行体检的60例健康人群作为对照组。采用酶联免疫双抗体夹心法检测血清netrin⁃4、Vitronectin水平,并进行组间比较。采用Pearson相关分析探讨血清netrin⁃4、Vitronectin与AIS患者神经功能、颈动脉内膜厚度的关系,应用多因素Logistic回归分析探讨影响AIS患者神经功能的相关因素。结果研究组血清Vitronectin水平明显高于对照组,血清netrin⁃4水平低于对照组,差异有统计学意义(P<0.05)。分组AIS患者血清Vitronectin水平比较:重度组>中度组>轻度组,差异有统计学意义(P<0.05);血清netrin⁃4水平比较:重度组<中度组<轻度组,差异有统计学意义(P<0.05)。动脉斑块组AIS患者血清Vitronectin水平明显高于无颈动脉斑块组,差异有统计学意义(P<0.05),血清netrin⁃4水平低于无颈动脉斑块组,差异有统计学意义(P<0.05)。血清netrin⁃4水平与NIHSS评分、颈动脉IMT值均呈负相关(r=-0.365、-0.410,P<0.001),血清Vitronectin水平与NIHSS评分、颈动脉IMT值均呈正相关(r=0.485、0.445,P<0.001)。多因素Logistic回归分析结果显示,血清netrin⁃4、Vitronectin均为AIS患者神经功能缺损程度的独立影响因素(P<0.05)。结论AIS患者血清中netrin⁃4水平降低,Vitronectin水平升高,且血清netrin⁃4、Vitronectin水平变化与神经功能缺损程度、颈动脉内膜厚度密切相关,二者能够作为评估AIS患者神经功能缺损程度与颈动脉内膜厚度的有效指标。
Objective To investigate the relationship between serum neuroguidance factor 4(netrin⁃4),vitronectin and neurological function and carotid intima thickness in patients with acute ischemic stroke(AIS).Methods A total of 116 AIS patients admitted to Chenzhou First People's Hospital from May 2019 to May 2020 were selected as the research group,and 60 healthy people who came to our hospital for check⁃up during the same period were selected as the control group.Serum levels of netrin⁃4 and Vitronectin were detected by enzyme⁃linked immunosorbent double⁃antibody sandwich method and were compared between groups.Pearson correlation analysis was used to explore the relationship between serum netrin⁃4,vitronectin and neurological function and carotid intima thickness in patients with AIS,and multivariate Logistic regression analysis was used to explore the related factors affecting neurological function in patients with AIS.Results The level of serum vitronectin in the study group was significantly higher than that in the control group,and the level of serum netrin⁃4 was lower than that in the control group(P<0.05).Serum levels of vitronectin in AIS patients in the severe group were significantly higher than those in the moderate and mild groups(severe group>moderate group>mild group,P<0.05),while serum netrin⁃4 levels were lower than those in the moderate and mild groups(Severe group<moderate group<mild group,P<0.05).The serum level of vitronectin in AIS patients in the arterial plaque group was significantly higher than that in the carotid plaque⁃free group(P<0.05),and the serum netrin⁃4 level was lower than that in the carotid plaque⁃free group(P<0.05).Serum netrin⁃4 level was negatively correlated with NIHSS score and carotid artery IMT value(r=-0.365,-0.410,P<0.001),and serum vitronectin level was positively correlated with NIHSS score and carotid artery IMT value(r=0.485,0.445,P<0.001).The results of multivariate Logistic regression analysis showed that serum netrin⁃4 and vitronectin were bo
作者
阳优
曹敏慧
何清
曾荣
YANG You;CAO Minhui;HE Qing;ZENG Rong(Department of Neurology,Chenzhou First People's Hospital,Chenzhou,Hunan,China,423000;Minimally Invasive Treatment Center of Tumor,East Hospital of Chenzhou First People's Hospital,Chenzhou,Hunan,China,423000)
出处
《分子诊断与治疗杂志》
2022年第5期785-788,共4页
Journal of Molecular Diagnostics and Therapy
基金
湖南省残疾人联合会康复科研项目(2020XK033)。
