摘要
目的:探究腹腔镜手术分别联合GnRH-a或孕三烯酮在治疗子宫内膜异位症患者中的临床疗效。方法:选取2014年1月—2019年6月武汉市第三医院收治的128例子宫内膜异位症患者,采用随机数表法将其随机分成两组,对照组接受腹腔镜手术联合孕三烯酮胶囊治疗,研究组接受腹腔镜手术联合使用GnRH-a治疗,比较两组的临床症状、性激素水平变化、随访妊娠率和副反应情况。结果:与对照组比,研究组的临床治疗效果更优(P<0.05);治疗后,与对照组比,研究组的雌二醇、促黄体生成素和促卵泡雌激素浓度等性激素指标更优(P<0.05);与对照组比,研究组在2年内的妊娠率更高(P<0.05),研究组的异常子宫出血、肝功能异常等不良反应发生率更低(P<0.05),但两组的体重增加及其他症状无明显差异(P>0.05)。结论:腹腔镜手术联合GnRH-a的应用可以有效优化各项性激素指标,提高2年后的妊娠率,降低治疗不良反应的发生率,安全性高,进一步增强临床治疗效果,值得推广应用。
Objective:To investigate the clinical efficacy of laparoscopic surgery combined with GnRH-a or gestrinone in the treatment of patients with endometriosis.Methods:A total of 128 cases of endometriosis patients admitted to Wuhan Third Hospital from January 2014 to June 2019 were randomly divided into two groups using a random number table method.The control group received laparoscopic surgery combined with getrienone capsule treatment,and the study group received GnRH-a combined with laparoscopic surgery treatment.The subjective symptom scores,sex hormone levels,pregnancy rate,recurrence rate,and adverse reactions were compared between the two groups.Results:Compared with that of the control group,the clinical treatment effect of the study group was better(P<0.05).After treatment,compared with those in the control group,the serum levels of estradiol,luteinizing hormone,and follicle-stimulating estrogen were better in the study group(P<0.05);the pregnancy rate in the study group was higher within one year(P<0.05),the incidence of adverse reactions such as vaginal bleeding and transaminase elevation were in the study group(P<0.05);and there was no significant difference in weight gain and other symptoms between the two groups(P>0.05).Conclusion:The application of GnRH-a combined with laparoscopic surgery can effectively optimize various sex hormone indicators,improve the pregnancy rate after one year,reduce the incidence of adverse reactions,with high safety and clinical efficacy,and is worthy of further application in clinic.
作者
阎蓓
邸石
代小燕
谢茂华
李哲郧
YAN Bei;DI Shi;DAI Xiaoyan;XIE Maohua;LI Zheyun(Wuhan Third Hospital&Tongren Hospital of Wuhan University,Wuhan 430060,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2022年第3期499-502,共4页
Medical Journal of Wuhan University
