摘要
目的:探讨双背侧前额叶低频重复经颅磁刺激(rTMS)辅助治疗对精神分裂症患者幻听症状的疗效和安全性。方法:采用随机双盲法将109例有幻听症状的精神分裂症患者分为rTMS组(55例)和对照组(54例);两组在维持原有抗精神病药种类及剂量的基础上,分别给予低频(1 Hz)rTMS真刺激和伪刺激治疗,每天1次、每次20 min、每周5次,疗程4周。分别于治疗前后采用阳性和阴性症状量表(PANSS)评定临床症状,以治疗后幻听症状评分减分≥2为有效;治疗后采用治疗中出现的症状量表(TESS)评估安全性。结果:治疗后rTMS组的PANSS总分、幻听症状分、阴性症状分、一般病理分显著低于对照组(P<0.05或P<0.01);幻听症状的有效率(72.7%)显著高于对照组(35.1%)(P<0.05);两组患者均无严重不良事件发生。结论:双背侧前额叶低频rTMS辅助治疗对精神分裂患者病情缓解及对症幻听症状有一定效果,且安全。
Objective:To investigate the efficacy and safety of low frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of auditory hallucinations in patients with schizophrenia.Method:109 schizophrenic patients with auditory hallucinations were randomly divided into rTMS group(n=55)and control group(n=54)by randomized and double blind way.On the basis of maintaining the original type and dose of antipsychotics,the two groups were treated with low-frequency(1 Hz)rTMS true stimulation or false stimulation,once a day,20 minutes each time,5 times a week for 4 weeks.The clinical symptoms were assessed by Positive and Negative Symptom Scale(PANSS)before and after treatment,and the reduction of auditory hallucination symptom score≥2 after treatment was effective.After treatment,the safety was evaluated by Treatment Emergent Symptom Scale(TESS).Results:After treatment,the total score of PANSS,scores of auditory hallucination symptoms,negative symptoms and general pathology in the rTMS group were significantly lower than those in the control group(P<0.05 or P<0.01).The effective rate of auditory hallucination symptoms(72.7%)was significantly higher than that in the control group(35.1%)(P<0.05).There were no serious adverse events in both groups.Conclusion:The low-frequency rTMS adjuvant therapy of double dorsal prefrontal lobes has a certain effect and safety on the remission of schizophrenia and symptomatic auditory hallucinations.
作者
戴伯坚
杨凌凯
涂献珠
刘立滢
邓江南
金晓庄
朱晶晶
陈杰
王芳
林崇光
孔令光
陈兴时
马俊
DAI Bo-jian;YANG Ling-kai;TU Xian-zhu;LIU Li-ying;DENG Jiang-nan;JIN Xiao-zhuang;ZHU Jing-jing;CHEN Jie;WANG Fang;LIN Chong-guang;KONG Ling-guang;CHEN Xing-shi;MA Jun(Wenzhou Seventh People's Hospital,Wenzhou 325005,China)
出处
《临床精神医学杂志》
CAS
2022年第3期177-179,共3页
Journal of Clinical Psychiatry
基金
温州市基础性科研项目(Y20190483)
南京市医学科技发展基金项目(YKK21236)。
关键词
精神分裂症
低频重复经颅磁刺激
幻听
schizophrenia
low frequency repetitive transcranial magnetic stimulation
auditory hallucinations
