摘要
银屑病是一种反复发作的炎症性皮肤疾病,常与代谢性疾病相关。目前的临床研究表明银屑病和非酒精性脂肪性肝病(NAFLD)可能存在密切的联系,但两种疾病之间联系的具体机制尚不完全明确。研究认为可能与代谢异常的重叠如肥胖、高脂血症、胰岛素抵抗和共通的炎症通路等有关。因两种疾病常可互为影响,因此探索银屑病和NAFLD之间的相关性以及发病机制,寻找银屑病人群发生NAFLD的有效预测因素,将有助于临床医生防治和管理银屑病与肝脏共患疾病。
Psoriasis is a recurrent inflammatory skin disease that is often associated with metabolic disorders.Current clinical studies suggest a possible close association between psoriasis and non-alcoholic fatty liver disease(NAFLD),but the exact mechanism of the link between the two diseases is not fully understood.Studies suggest that it may be related to the overlap of metabolic abnormalities such as obesity,hyperlipidemia,insulin resistance and common inflammatory pathways.Because the two diseases can often interact with each other,exploring the correlation and pathogenesis between psoriasis and NAFLD,and finding effective predictors of NAFLD in the psoriasis population will help clinicians to prevent and manage psoriasis and liver co-morbidities.
作者
刘克帅
高敏
张晓艳
LIU Keshuai;GAO Min;ZHANG Xiaoyan(Beijing University of Chinese Medicine,Beijing 100029;Department of Dermatology,China-Japan Friendship Hospital,Beijing 100029)
出处
《皮肤病与性病》
2022年第2期115-120,142,共7页
Dermatology and Venereology
关键词
银屑病
非酒精性脂肪性肝病
代谢性共病
Psoriasis
Non-alcoholic fatty liver disease
Metabolic co-morbidity
