摘要
目的 探讨饮食控制联合有氧运动对肥胖青少年胰岛素抵抗、体成分、血浆致动脉粥样硬化指数、炎症因子的影响。方法 选择2016年8月-2018年7月我院内分泌科收治的肥胖青少年140例,采用随机数字表法分为对照组和观察组,每组70例。对照组肥胖青少年采取运动方式,观察组在此基础上联合饮食控制。此外,观察组青少年另分为肥胖组【24≤体重指标(BMI)<27.9,n=41】和超重组(BMI≥28,n=29)。12周调整后,比较各组青少年空腹血糖(FPG),总胆固醇(TC)、甘油三酯(TG),空腹胰岛素(FINS)、计算胰岛素抵抗指数(HOMA-IR)、血瘦素(leptin)、BMI、腰臀比。结果 经过12周的运动联合饮食控制,各组青少年FPG、TC、TG水平均较12周前下降,观察组青少年下降程度高于对照组,超重组青少年下降程度高于肥胖组,差异有统计学意义(P<0.05);各组青少年FINS、HOMA-IR指数及leptin均低于治疗前,然而观察组下降程度高于对照组,超重组青少年下降程度高于肥胖组,差异有统计学意义(P<0.05);各组青少年BMI、腰臀比、Fat%、FM均低于治疗前,LBM高于治疗前,观察组较对照组变化更明显,超重组青少年较肥胖组变化更明显,差异有统计学意义(P<0.05);两组青少年AIP、IL-18均低于治疗前,观察组较对照组下降更明显,超重组青少年较肥胖组变化更明显,差异有统计学意义(P<0.05)。结论 合理饮食联合运动处方可以有效改善肥胖青少年的胰岛素抵抗、糖脂代谢、体成分、IL-18、AIP,因此值得临床医师推广实施。
Objective To investigate the effects of diet control combined with aerobic exercise on insulin resistance, body composition, plasma atherogenic index and inflammatory cytokines in obese adolescents.Methods From August 2016 to July 2018,140 obese adolescents admitted to Department of Endocrinology in our hospital were divided into control group and observation group using random number table, with 70 cases in each group.The control group of obese adolescents take exercise, the observation group on this basis, combined with diet control.After adjustment for 12 weeks, fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),fasting insulin(FINS),calculating insulin resistance index(HOMA-IR),leptin,BMI,waist-hip ratio.Results After 12 weeks of exercise combined with diet control, the levels of FPG,TC,and TG of adolescents in each group decreased compared with that of 12 weeks ago.The decrease of adolescents in the observation group was higher than that of the control group, and the decrease in overweight adolescents was higher than that of the obese group(P<0.05);The FINS,HOMA-IR index and leptin of adolescents in each group were lower than before treatment.However, the decline in the observation group was higher than that in the control group, and the decline in overweight adolescents was higher than that in the obesity group.The difference was statistically significant(P<0.05);The BMI,waist-to-hip ratio, Fat% and FM of the adolescents in each group were lower than before treatment, and LBM was higher than before treatment.The changes in the observation group were more obvious than those in the control group, and the changes in overweight adolescents were more obvious than those in the obese group.The difference was statistically significant(P<0.05);The AIP and IL-18 of the two groups of adolescents were lower than before treatment, the observation group decreased more significantly than the control group, and the overweight adolescents changed more significantly than the obesity group.The difference was st
作者
梁碧瑜
阮世冲
谭国据
陈俏容
许燕
Liang Biyu;Ruan Shichong;Tan Guoju;Chen Qiaorong;Xu Yan(Yangjiang Hospital,Yangjiang 529500,Guangdong)
出处
《辽宁医学杂志》
2022年第3期74-78,共5页
Medical Journal of Liaoning
