摘要
术中识别甲状旁腺是甲状腺癌手术中重要的外科技术。裸眼识别依靠外科医师的经验。正显影识别主要包括5-氨基乙酰丙酸、吲哚菁绿、亚甲蓝,通过全身静脉注射,副反应严重,临床未广泛应用。目前临床主要应用纳米碳、米托蒽醌两类负显影识别,但纳米碳不可降解,米托蒽醌有细胞毒性,有待优化性能。新近甲状旁腺自体荧光显影技术兴起,研究结论尚不一致,无靶向性,存在一定假阳性。未来基于荧光技术,研发特异性的甲状旁腺正显影是发展的重要趋势。
Intraoperative identification of parathyroid gland is an important surgical technique in the thyroid carcinoma operation,and naked eye recognition depends on the experience of surgeons.Positive tone developers,including 5-aminolevulinic acid,indocyanine green and methylene blue,are applied by intravenous injection with serious side effects,and have not been widely used clinically.At present,two negative tone developers including nano-carbon and mitoxantrone are mainly used in clinic;however,nano-carbon is non-degradable and mitoxantrone is cytotoxic,both need to be optimized.The autologous fluorescence imaging of parathyroid gland is an emerging technique,but its application is still controversial,since the technique is not targeting and with a certain false positive rate.Based on fluorescence technique,the specific imaging technique for identification of parathyroid gland is an important direction of development in the future.
作者
郑伟慧
王可敬
ZHENG Wei-hui;WANG Ke-jing(The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Key Laboratory of Head&Neck Cancer Translational Research of Zhejiang Province,Hangzhou 310022,China)
出处
《肿瘤学杂志》
CAS
2022年第4期327-331,共5页
Journal of Chinese Oncology
基金
浙江省医药卫生科技计划项目(2021KY110)。
关键词
甲状旁腺
显影技术
甲状腺手术
parathyroid glands
imaging technology
thyroid surgery
