摘要
目的探讨脓毒症患儿胃肠功能障碍的发生率、病死率,应用近红外光谱技术(near-infrared spectroscopy,NIRS)监测肠系膜局部组织血氧饱和度(regional oxygen saturation,rSO_(2)),观察胃肠功能障碍患儿rSO_(2)差异。方法前瞻性选择2021年1~12月儿科重症监护病房79例脓毒症患儿(脓毒症组)及儿童保健科40例健康体检儿童(健康对照组)为研究对象,收集患儿入院及出院基本情况、在院治疗情况和实验室检查指标,应用NIRS测定肠系膜rSO_(2),根据有无胃肠功能障碍发生进行组间对比。结果79例脓毒症患儿胃肠功能障碍发生率为49%(39/79),胃肠功能障碍患儿28 d病死率为26%(10/39)。胃肠功能障碍患儿机械通气时间更长、28 d病死率更高(P<0.05)。胃肠功能障碍患儿肠系膜rSO_(2)(64%)低于无胃肠功能障碍患儿(72%)及健康对照组(78%)(P<0.05)。结论脓毒症患儿胃肠功能障碍发生率及病死率较高,影响患儿预后。肠系膜rSO_(2)的降低与胃肠功能障碍发生相关。
Objective To investigate the incidence and mortality of gastrointestinal dysfunction in children with sepsis,the application of near-infrared spectroscopy(NIRS)in monitoring mesenteric regional tissue oxygen saturation(rSO_(2)),and the association between rSO_(2) and gastrointestinal dysfunction.Methods In this prospective study,79 children with sepsis in the pediatric intensive care unit(sepsis group)and 40 children who underwent physical examination in the Department of Child Healthcare(healthy control group)from January to December,2021 were enrolled as subjects.The related medical data were collected,including general information on admission and at discharge,treatment during hospitalization,and laboratory examination results.NIRS was used to measure mesenteric rSO_(2).Clinical characteristics were compared between the patients with and without gastrointestinal dysfunction.Results For the 79 children with sepsis,the incidence rate of gastrointestinal dysfunction was 49%(39/79),and the mortality rate of the children with gastrointestinal dysfunction was 26%(10/39).The children with gastrointestinal dysfunction had a longer duration of mechanical ventilation and a higher 28-day mortality rate(P<0.05).The children with gastrointestinal dysfunction had a significantly lower median rSO_(2)(64%)than the children without gastrointestinal dysfunction(72%)and the healthy control group(78%)(P<0.05).Conclusions There are high incidence and mortality rates of gastrointestinal dysfunction in children with sepsis,and the reduction in rSO_(2)may be associated with the development of gastrointestinal dysfunction.
作者
姚德贞
王丽杰
YAO De-Zhen;WANG Li-Jie(Pediatric Intensive Care Unit,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2022年第6期620-625,共6页
Chinese Journal of Contemporary Pediatrics
关键词
脓毒症
胃肠功能障碍
近红外光谱技术
儿童
Sepsis
Gastrointestinal dysfunction
Near-infrared spectroscopy
Child
