摘要
目的探讨β-连环蛋白(β-catenin)、c-myc、p16在鼻腔鼻窦黏膜黑色素瘤(sinonasal mucosal melanoma,SNM)中的表达及临床意义。方法采用免疫组化Multimer法检测85例未接受放化疗和靶向治疗的原发性SNM组织中β-catenin、c-myc和p16的表达,分析其与临床病理特征、预后的关系,并分析三者表达的相关性。结果SNM中β-catenin、c-myc、p16表达阳性患者的肿瘤淋巴结转移率分别为69.7%、74.1%和76.4%,均高于阴性表达患者,差异有统计学意义(P均<0.05)。c-myc阳性、p16强阳性表达患者的总生存期和无病生存期低于阴性表达患者(P均<0.05),β-catenin与生存期无明显相关性。c-myc的表达与β-catenin的表达呈正相关(r=0.234,P=0.027)。结论SNM中β-catenin、c-myc、p16阳性表达是肿瘤淋巴结转移的重要预测因子。c-myc阳性、p16强阳性表达患者总生存期和无病生存期较短,提示预后差,可以作为判断SNM预后的重要参考指标。
Objective To investigate the expression ofβ-catenin,c-myc and p16 in sinonasal mucosal melanoma(SNM)and its clinical significance.Methods Immunohistochemical Multimer was used to detect the expression ofβ-catenin,c-myc and p16 in 85 primary SNM samples that had not received chemoradiotherapy or targeted therapy.The correlation between the expression ofβ-catenin,c-myc,p16 and clinicopathological features and prognosis was analyzed.The correlation between the expression of β-catenin,c-myc and p16 was analyzed.Results The lymph node metastasis rates ofβ-catenin,c-myc and p16 positive patients in SNM were 69.7%,74.1%and 76.4%,respectively,which were all higher than those of patients with low expression,and the differences were statistically significant(P all<0.05).The overall survival and disease-free survival of c-myc positive patients and p16 strongly positive patients were lower than those of negative patients(P all<0.05).There was no significant correlation between expression ofβ-catenin with survival rate.The expression of c-myc was positively correlated with the expression ofβ-catenin(r=0.234,P=0.027).Conclusion The positive expression ofβ-catenin,c-myc and p16 in SNM was an important predictor of lymph node metastasis.Shorter overall survival and disease-free survival in patients with positive c-myc expression and strongly positive p16 expression suggest poor prognosis,which can be used as an important reference index to judge the prognosis of SNM.
作者
石林
翟长文
袁存存
王纾宜
SHI Lin;ZHAI Chang-wen;YUAN Cun-cun;WANG Shu-yi(Department of Pathology,Eye,Ear,Nose and Throat Hospital,Fudan University,Shanghai 200031,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2022年第3期369-375,共7页
Fudan University Journal of Medical Sciences
