摘要
目的:分析静脉导管血流频谱参数与血中抑制素A(inhibinA)、神经轴突导向因子1(Netrin-1)水平相关性及对胎儿染色体异常的诊断价值。方法:选取2018年7月—2020年7月在本院就诊的疑似胎儿染色体异常孕妇100例,根据胎儿染色体核型分析确诊为胎儿染色体异常52例(异常组),非染色体异常48例为对照组。均采用彩色多普勒超声检查,对比两组RI、PI、S/a参数,分析阻力指数(RI)、搏动指数(PI)、S/a参数与inhibinA、Netrin-1的相关性,以及对胎儿染色体异常的诊断价值。结果:异常组RI、PI、S/a参数高于对照组,且在染色体异常、神经系统畸形、心脏畸形者中逐渐升高,染色体异常、神经系统畸形、心脏畸形患者inhibinA、Netrin-1表达逐渐降低(均P<0.05)。RI、PI、S/a与异常组不同病情类型正相关,inhibinA、Netrin-1与研究组不同病情类型负相关;RI、PI、S/a与inhibinA、Netrin-1水平均负相关(均P<0.05)。RI、PI、S/a联合诊断胎儿染色体异常价值高于单项诊断,曲线下面积为0.847,敏感度98.2%。结论:静脉导管血流频谱参数、inhibinA、Netrin-1水平对诊断胎儿染色体异常有一定临床价值。
Objective:To analyze the correlation between venous catheter blood flow spectrum parameters of pregnant women and their inhibinA and Netrin-1 levels,and to study the diagnostic value of the blood flow spectrum parameters and the levels of inhibinA and Netrin-1 of the women for their fetal chromosomal abnormality.Methods:A total of 100 pregnant women with suspected fetal chromosomal abnormalities who had accepted examination of color Doppler ultrasonography were selected from July 2018 to July 2020.According to the gold standard of fetal chromosomal karyotype analysis,52 cases with confirmed fetal chromosomal abnormalities were selected in study group,and 48 cases without confirmed fetal chromosomal abnormalities were selected in control group.The values of venous catheter blood flow spectrum parameters,such as resistance index(RI),pulsatile index(PI),and S/a of the women were compared between the two groups.The correlation between the values of RI,PI,S/a of the women and their inhibinA and Netrin-1 levels was analyzed.The diagnostic value of the values of RI,PI,and S/A for fetal chromosomal abnormalities was also analyzed.Results:The values of RI,PI,and S/a of the women in the study group were significantly higher than those of the women in the control group,and which of the women with fetal chromosomal abnormality,nervous system abnormality,and heart abnormality had increased gradually.The expression levels of inhibinA and Netrin-1 of the women with fetal chromosomal abnormalities,nervous system abnormality,and heart abnormality had decreased gradually(all P<0.05).In the study group,the values of RI,PI,and S/a of the women were positively correlated with their different disease types,while the levels of inhibinA and Netrin-1 of the women were negatively correlated with their different disease types,the values of RI,PI,and S/a of the women were negatively correlated with their inhibinA and Netrin-1 levels(all P<0.05).The combined values of RI,PI,and S/a for diagnosing fetal chromosome abnormality was significantl
作者
冯伶艳
郗红雪
孙舒婷
FENG Lingyan;XI Hongxue;SUN Shuting(Daxing Teaching Hospital,Capital Medical University,Beijing,102600)
出处
《中国计划生育学杂志》
2022年第6期1388-1391,共4页
Chinese Journal of Family Planning
