摘要
目的系统评价针灸治疗阿片类药物相关性便秘(OIC)的临床疗效。方法检索中国知识资源总库(CNKI)、万方数据知识服务平台(万方数据)、中文科技期刊数据库(维普网)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Cochrane Library建库至2021年12月31日关于针灸治疗OIC的随机对照试验(RCT)文献,使用RevMan5.4软件进行Meta分析。结果最终纳入RCT 18篇,涉及患者1655例。Meta分析结果提示:与对照组相比,针灸治疗OIC在有效率(参照《中药新药临床研究指导原则》:RR=1.23,95%CI[1.16,1.30],P<0.00001;参照《中医病证诊断疗效标准》:RR=1.31,95%CI[1.18,1.46],P<0.00001;参照《便秘中医诊疗专家共识意见(2017)》:RR=1.21,95%CI[0.91,1.61],P=0.19)、痊愈率(参照《中药新药临床研究指导原则》:RR=2.36,95%CI[1.73,3.22],P<0.00001;参照《中医病证诊断疗效标准》:RR=1.27,95%CI[0.96,1.66],P=0.09)、克利夫兰便秘评分量表评分(SMD=-0.87,95%CI[-1.07,-0.66],P<0.00001)、便秘患者生活质量量表评分(SMD=-0.38,95%CI[-0.60,-0.16],P=0.0008)、Karnofsky功能状态评分(SMD=0.67,95%CI[0.50,0.85],P<0.00001)上均具有优势。结论依据现有研究,针灸治疗OIC疗效显著,可缓解患者排便困难,提高生活质量,改善功能状态。
Objective To systematically evaluate the clinical efficacy of acupuncture and moxibustion in the treatment of opioid-induced constipation(OIC).Methods RCTs about acupuncture and moxibustion in the treatment of OIC were retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed,Web of Science and Cochrane Library from the establishment of the databases to December 31,2021.RevMan 5.4 software was used for Meta-analysis of the literature included in the study.Results Totally 18 RCTs were included,involving 1655 cases.Meta-analysis showed that compared with the control group,the acupuncture and moxibustion treatment for OIC had significant advantages in the efficiency(according to the Guideline for Clinical Study of New Chinese Medicines:RR=1.23,95%CI[1.16,1.30],P<0.00001;according to the Criteria for Diagnosis and Treatment of Diseases in Traditional Chinese Medicine:RR=1.31,95%CI[1.18,1.46],P<0.00001;according to the Experts Consensus on the Diagnosis and Treatment of Constipation in Traditional Chinese Medicine(2017):RR=1.21,95%CI[0.91,1.61],P=0.19),curability(according to the Guideline for Clinical Study of New Chinese Medicines:RR=2.36,95%CI[1.73,3.22],P<0.00001;according to the Criteria for Diagnosis and Treatment of Diseases in Traditional Chinese Medicine:RR=1.27,95%CI[0.96,1.66],P=0.09),CCS(SMD=-0.87,95%CI[-1.07,-0.66],P<0.00001),PAC-QOL(SMD=-0.38,95%CI[-0.60,-0.16],P=0.0008),KPS(SMD=0.67,95%CI[0.50,0.85],P<0.00001).Conclusion According to the existing research,the treatment of acupuncture and moxibustion for the OIC has significant efficiency,which can relieve the difficulty of defecation,improve the quality of life and improve the functional state.
作者
吴霞
刘敏
王圆圆
赵文硕
张青
WU Xia;LIU Min;WANG Yuanyuan;ZHAO Wenshuo;ZHANG Qing(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2022年第6期43-48,共6页
Chinese Journal of Information on Traditional Chinese Medicine
基金
首都卫生发展专项(2018-3-2232)
恩施州科技计划研究与开发项目(JCY2019000040)。
关键词
针灸
治疗
阿片类药物
便秘
META分析
随机对照试验
acupuncture and moxibustion
treatment
opioids
constipation
Meta-analysis
randomized controlled trials
