摘要
目的 探讨内镜下经鼻蝶窦入路(EETA)行脑垂体瘤切除术后并发颅内感染影响因素。方法 回顾性分析行EETA脑垂体瘤切除术治疗的108例脑垂体瘤患者的临床资料,分析EETA脑垂体瘤切除术后并发颅内感染的相关因素。结果 108例患者术后并发颅内感染16例(14.81%);单因素分析显示:合并糖尿病、年龄、手术时间、合并脑脊液漏、肿瘤类型与EETA脑垂体瘤切除术后并发颅内感染有关,差异有统计学意义(P<0.05);年龄、体质指数(BMI)、性别、术前使用抗菌药物、术后使用激素、术前垂体功能低下、术后使用抗菌药物时间、术中出血量与EETA脑垂体瘤切除术后并发颅内感染无关,差异无统计学意义(P>0.05);多因素分析显示:合并糖尿病、年龄≥60岁、手术时间≥4 h、合并脑脊液漏、生长激素型是EETA脑垂体瘤切除术后并发颅内感染的高危因素(P<0.05)。结论 EETA脑垂体瘤切除术后并发颅内感染与年龄、合并糖尿病、手术时间、合并脑脊液漏、肿瘤类型密切相关,针对各危险因素制定干预措施,有助于减少颅内感染发生。
Objective To investigate the influence factors of intracranial infection after endoscopic transsphenoidal approach(EETA) and pituitary adenoma resection.Methods The clinical data of 108 patients with pituitary adenoma treated by EETA resection were retrospectively analyzed,Analyze the related factors of intracranial infection after EETA pituitary adenoma resection.Results There were 16 cases of postoperative intracranial infection in 108 patients(14.81%);A single factor analysis showed that diabetes,age,operative time,cerebrospinal fluid leakage and tumor type were associated with intracranial infection after EETA pituitary adenoma resection,difference was statistically significant(P<0.05);age,body mass index(BMI),sex,preoperative use of antimicrobial agents,postoperative use of hormones,preoperative hypophysis function,postoperative use of antimicrobial agents time,intraoperative blood loss was not associated with intracranial infection after EETA pituitary adenoma resection,(b) The difference was not statistically significant(P>0.05);Multivariate analysis showed that diabetes mellitus,age ≥60 years,operation time ≥4 h、cerebrospinal fluid leakage,growth hormone type were the high risk factors for intracranial infection after EETA pituitary adenoma resection(P<0.05).Conclusion EETA intracranial infection after pituitary adenoma resection is closely related to age,diabetes,operative time,cerebrospinal fluid leakage and tumor type,Developing interventions for risk factors,It helps to reduce the incidence of intracranial infection.
作者
姚春旭
冯婷
牛鑫焱
张元峰
YAO Chunxu;FENG Ting;NIU Xinyan(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2022年第6期1016-1018,1031,共4页
The Practical Journal of Cancer
基金
河南省科技攻关计划(编号:10511232040)。
关键词
脑垂体瘤
颅内感染
脑垂体瘤切除术
经鼻蝶窦入路
内镜
影响因素
Pituitary adenoma
Intracranial infection
Pituitary adenoma resection
Transsphenoidal approach
Endoscopy
Influencing factors
