摘要
糖尿病是一种以胰岛素抵抗和血糖升高等代谢紊乱为特征的慢性疾病,并发症是其主要的危险因素,高血糖水平与动脉粥样硬化密切相关。我国约20%~40%的糖尿病患者合并糖尿病肾病,而有些2型糖尿病患者早在原发病诊断之前就已合并糖尿病视网膜病变。糖化白蛋白是评价糖尿病患者短期糖代谢控制水平的良好指标之一,其作为循环糖化蛋白中的主要组成成分,通过多种途径在糖尿病患者并发症的发生发展中起着重要作用。近年来诸多研究中描述了糖尿病和炎症以及生物标志物之间的关系,本文将以炎症为线索,对糖化白蛋白在冠心病、糖尿病视网膜病变及糖尿病肾病等糖尿病常见并发症发生发展中的作用进行综述。
Diabetes mellitus is a chronic disease characterized by metabolic disorders such as insulin resistance and elevated blood sugar,and the existence of complications is its main risk factor.High blood glucose level is closely related to atherosclerosis.About 20%to 40%of diabetic patients in China are complicated with diabetic nephropathy.And some people with type 2 diabetes as early as in primary disease diagnosis before merger diabetic retinopathy,glycated albumin is a short-term glucose metabolism in patients with diabetes control a good indicator of the level of glycosylated protein as a cycle,the main composition,through a variety of ways in the development of diabetic complications plays an important role.The relationship between diabetes and inflammation and biomarkers has been described in many studies in recent years.In this paper,the role of glycosylated albumin in the development and development of common diabetic complications such as coronary heart disease,diabetic retinopathy and diabetic nephropathy was reviewed by using inflammation as a clue.
作者
李慧伟
刘长梅
秦明
LI Huiwei;LIU Changmei;QIN Ming(Department of Endocrinology and Metabolism,Binzhou Medical University Hospital,Shandong Province,Binzhou256603,China;Department of Internal Medicine,Liaocheng Third People's Hospital,Shandong Province,Liaocheng252200,China)
出处
《中国当代医药》
CAS
2022年第14期32-35,共4页
China Modern Medicine
关键词
糖化白蛋白
炎症
糖尿病并发症
研究进展
Glycosylated albumin
Diabetic complication
Inflammation
Research progress
