摘要
目的探讨利伐沙班对老年髋部周围骨折患者围术期下肢深静脉血栓形成(DVT)的预防价值。方法选取2019年6月至2020年12月于我院治疗的119例老年髋部周围骨折患者为研究对象,按照随机分配法将患者分为研究组(n=59)和对照组(n=60)。对照组患者在术后12 h采用低相对分子质量肝素(LMWH)皮下注射治疗,研究组患者在术后12 h采用利伐沙班片口服治疗。观察比较两组患者手术前后血小板和血红蛋白情况、DVT发生率及不良反应发生情况。结果术前和术后1 d、10 d,两组患者血小板和血红蛋白情况比较无明显统计学意义(P>0.05);术后随访3个月时间内,两组患者DVT发生率比较无明显统计学意义(P>0.05);两组均无不良反应发生。结论老年髋部周围骨折患者口服利伐沙班和皮下注射LMWH对围术期DVT均有较好的预防作用,但利伐沙班口服治疗更为方便。
Objective To explore the preventive value of rivaroxaban on deep venous thrombosis(DVT)of lower limbs in elderly patients with perihip fracture.Methods 119 elderly patients with perihip fractures treated in our hospital from June 2019 to December 2020 were selected as research objects,and were randomly divided into study group(n=59)and control group(n=60).Patients in the control group were treated with hypodermic injection of low molecular weight heparin(LMWH)at 12 hours after operation,while patients in the study group were treated with rivaroxaban tablets orally at 12 hours after operation.The platelet and hemoglobin,DVT formation and adverse reactions were observed and compared between the two groups before and after operation.Results There was no significant difference in platelet and hemoglobin between the two groups before operation and 1 day and 10 days after operation(P>0.05).During the follow-up period of 3 months,there was no significant difference in DVT incidence between the two groups(P>0.05).No adverse reactions occurred in both groups.Conclusion Both oral rivaroxaban and subcutaneous injection of low molecular weight heparin in elderly patients with hip fracture have good preventive effects on perioperative DVT,but oral rivaroxaban is more convenient.
作者
薛茜
张欢欢
XUE Qian;ZHANG Huan-huan(Department of Geriatrics,215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)
出处
《血栓与止血学》
CAS
2022年第3期558-559,562,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
髋部周围骨折
围术期
深静脉血栓形成
利伐沙班
Perihip fracture
Perioperative period
Deep venous thrombosis
Rivaroxaban
