摘要
目的:探讨沙丁胺醇联合布地奈德治疗哮喘-慢阻肺重叠综合征(ACOS)患者的效果及对免疫指标的影响。方法:按照随机数字表法将某院2019年6月-2021年4月期间收治的65例ACOS患者分为对照组33例和观察组32例,对照组采用沙丁胺醇治疗,观察组在对照组基础上联合布地奈德治疗。观察两组临床疗效、肺功能、ACT评分和CAT评分、炎症水平以及免疫指标。结果:治疗3个月后,观察组总有效率高于对照组(93.75%vs 69.70%)(P<0.05);观察组ACT评分高于对照组,CAT评分低于对照组(P<0.05);观察组CRP、PCT、IL-6、TNF-α水平低于对照组(P<0.05);观察组Th1、Th1/Th2水平高于对照组(P<0.05)。结论:对ACOS予以上述用药方案治疗,可改善免疫功能,降低炎症反应,提高肺功能,促进症状缓解,进而提高临床疗效。
Objective:To explore the effect of salbutamol combined with budesonide on patients with asthma-chronic obstructive pulmonary syndrome(ACOS)and its influence on immune indexes.Methods:According to the random number table method,65 ACOS patients in a hospital from June 2019 to April 2021 were divided into two groups,33 cases in the control group were treated with salbutamol and 32 cases in the observation group were treated with budesonide on the basis of the control group.The clinical curative effect,lung function,ACT score and CAT score,inflammation level,and immune indexes of the two groups were observed.Results:After 3 months of treatment,the total effective rate of the observation group was higher than that of the control group(93.75%vs 69.70%)(P<0.05).The ACT score of observation group was higher than that of control group,while the CAT score was lower than that of control group(P<0.05).The levels of CRP,PCT,IL-6 and TNF-αin observation group were lower than those in control group(P<0.05).The levels of Th1 and Th1/Th2 in observation group were higher than those in control group(P<0.05).Conclusion:The salbutamol combined with budesonide in the treatment of ACOS can improve immune function,reduce inflammatory reactions,improve lung function,promote symptom relief,and then improve clinical efficacy.
作者
程丽霞
Cheng Lixia(Department of Respiratory Medicine,Putian Medical District,the 900th Hospital of the Joint Logistic Support Force,Futian 351199)
出处
《数理医药学杂志》
CAS
2022年第6期866-868,共3页
Journal of Mathematical Medicine
