摘要
目的:探讨甲泼尼龙结合头孢呋辛对重症肺炎(SP)患者炎性反应及免疫功能的影响。方法:采用随机数字表法选取某院2017年1月-2019年12月就诊的SP患者130例分为对照组和观察组各65例,对照组给予头孢呋辛进行常规治疗,观察组在对照组基础上联合静脉滴注甲泼尼龙进行治疗。比较两组患者的临床指标、炎性反应指标及免疫功能指标。结果:观察组患者体温恢复至正常时间及住院时间均比对照组短,差异有统计学意义(P<0.05);治疗前观察组和对照组的血清白细胞介素6(IL-6)、白细胞介素10(IL-10)指标对比,差异无统计学意义(P>0.05),治疗后观察组和对照组的血清白细胞介素6(IL-6)水平低于治疗前,观察组和对照组的血清白细胞介素10(IL-10)水平高于治疗前,且观察组白细胞介素6(IL-6)水平比对照组低,观察组的血清白细胞介素10(IL-10)比对照组白细胞介素10(IL-10)高,差异有统计学意义(P<0.05);治疗前观察组和对照组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平对比,差异无统计学意义(P>0.05),治疗后观察组和对照组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均比治疗前高,且观察组比对照组高,差异有统计学意义(P<0.05)。结论:SP患者采用甲泼尼龙结合头孢呋辛治疗的效果较好,有助于调节炎性因子水平,调节免疫功能,促进患者康复。
Objective:To investigate the effect of methylprednisolone combined with cefuroxime on inflammatory response and immune function in patients with severe pneumonia.Methods:A total of 130 patients with severe pneumonia treated in a hospital from January 2017 to December 2019 were selected and divided into control group(65 cases)and observation group(65 cases)by random number table method.The control group was given cefuroxime for routine treatment,the observation group was treated with intravenous methylprednisolone on the basis of control group.The clinical indexes,inflammatory response indexes and immune function indexes of two groups were compared.Results:The time of body temperature return to normal and hospitalization time in the observation group were shorter than those in the control grou,and the difference was statistically significant(P<0.05);Before the treatment,there was no significant difference in serum interleukin-6(IL-6),interleukin 10(IL-10)between the two groups(P>0.05).After treatment,serum interleukin-6(IL-6)level in the two groups was lower than that before treatment,and serum interleukin-10(IL-10)level in the two groups was higher than that before treatment.The level of interleukin 6(IL-6)in the observation group was lower than that in the control group,the serum interleukin 10(IL-10)in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)between the observation group and the control group(P>0.05).After treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in observation group and control group were higher than those before treatment,the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Conclusion:Methylprednisolone combined with cefuroxime in the treatment of patients with severe pneumonia treated with has better effect,which helps to regulate the levels of inflammatory factors,re
作者
姬银平
Ji Yinping(Emergency Department,The First Affiliated Hospital of Henan University of Scienceand Technology,Luoyang 471000)
出处
《数理医药学杂志》
CAS
2022年第6期852-855,共4页
Journal of Mathematical Medicine
关键词
重症肺炎
甲泼尼龙
头孢呋辛
炎性反应
免疫功能
severe pneumonia
methylprednisolone
cefuroxime
inflammatory response
immune function
