摘要
胰岛素样生长因子2 mRNA结合蛋白2(IGF2BP2/IMP2)是一种重要的RNA结合蛋白,可以与IGF2 mRNA及其他多个靶mRNA结合,稳定并介导其翻译。IGF2BP2可以通过参与mRNA的m6A甲基化修饰、激活MAPK、PI3K/Akt信号通路等多种方式参与细胞分化、增殖及能量代谢。近年来IGF2BP2在生殖系统中的作用备受关注,多项研究发现其可能影响原始生殖细胞数量、初级卵母细胞发育,以及颗粒细胞增殖等过程,并与多囊卵巢综合征、卵巢癌等疾病的发生发展有关。本文就IGF2BP2与卵巢功能及相关疾病的研究进展进行综述。
Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2/IMP2)is an important RNA binding protein,which can bind to IGF2 mRNA and other target mRNAs to stabilize and mediate their translation.IGF2BP2 participates in cell differentiation,proliferation and energy metabolism by regulating m6A methylation modification of mRNA,activating MAPK,PI3K/Akt signaling pathway.Recently,the related role of IGF2BP2 in the reproductive system has attracted much attention.Many studies have found that it may affect the number of primordial germ cells,the development of primary oocyte and proliferation of granulosa cells.It also relates to the occurrence and development of diseases such as polycystic ovary syndrome,ovarian cancer and so on.Therefore,this article reviews the research progress of IGF2BP2 and ovarian related disease.
作者
张子瑜
赵飞燕
杨晓葵
ZHANG Ziyu;ZHAO Feiyan;YANG Xiaokui(Department of Human Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《中国优生与遗传杂志》
2022年第5期901-904,共4页
Chinese Journal of Birth Health & Heredity
基金
北京市医院管理中心临床医学发展专项经费资助(ZYLX201830)
北京市医院管理中心“登峰”计划专项经费资助(DFL20191401)。
