摘要
目的分析老年高血压患者认知功能障碍中炎症因子的表达水平及相关性。方法回顾性分析我院自2019年1月至2021年10月收治的老年高血压患者112例的临床资料,采用简易精神状态量表(MMSE)对全部患者的认知功能进行评价,按照是否出现了认知功能障碍分为认知功能障碍组(n=58)及非认知功能障碍组(n=54),对比两组患者的一般资料(性别、年龄、体质量、受教育程度)、高血压病程、吸烟史、饮酒史、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、尿酸、炎症因子[超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平,对两组表现出明显差异性的因素纳入相关性分析中,探讨这些因素与MMSE评分的相关性。结果认知功能障碍组与非认知功能障碍组的性别、年龄、身体质量指数、受教育程度、高血压病程、收缩压、舒张压、心率、吸烟史、饮酒史、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、尿酸水平相比差异无统计学意义(P>0.05)。认知功能障碍组与非认知功能障碍组相比hs-CRP、IL-6水平较低,差异有统计学意义(P<0.05)。hs-CRP、IL-6水平与MMSE评分进行Pearson分析可见,hs-CRP水平与MMSE评分未呈现出明显的相关性(P>0.05),IL-6与MMSE评分之间呈现明显的负相关性(P<0.05)。结论在老年高血压认知功能障碍患者中炎症因子水平多呈现出异常升高的趋势,且血清IL-6的水平与老年高血压患者认知功能严重程度具有密切的相关性。
Objective To explore and analyze the expression levels and correlations of inflammatory factors in cognitive dysfunction in elderly hypertensive patients.Methods The clinical data of 112 elderly hypertensive patients admitted to our hospital from January 2019 to October 2021 were retrospectively analyzed,and the cognitive function of all patients was evaluated by the Mini Mental State Scale(MMSE).Cognitive dysfunction occurred and were divided into cognitive dysfunction group(n=58)and non-cognitive dysfunction group(n=54).The general data(gender,age,body weight,education level)of the two groups were compared,Duration of hypertension,smoking history,drinking history,fasting blood sugar,total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein,uric acid,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),leukocyte interleukin The level of IL-6(IL-6)],the factors that showed significant differences between the two were included in the correlation analysis to explore the correlation between these factors and the MMSE score.Results Gender,age,body mass index,education level,course of hypertension,systolic blood pressure,diastolic blood pressure,heart rate,smoking history,drinking history,fasting blood glucose,total cholesterol in the cognitive impairment group and the non-cognitive dysfunction group,triglyceride,triglyceride,low-density lipoprotein,high-density lipoprotein,and uric acid levels were not significantly different(P>0.05).Compared with the non-cognitive dysfunction group,the levels of hs-CRP and IL-6 in the cognitive dysfunction group were lower,and the difference was statistically significant(P<0.05).The Pearson analysis of hs-CRP,IL-6 levels and MMSE scores showed that there was no significant correlation between hs-CRP levels and MMSE scores(P>0.05),while there was no significant correlation between IL-6 levels and MMSE scores.There was a significant negative correlation(P<0.05).Conclusion The levels of inflammatory factors tend to be abnormally elevated in elderly hyp
作者
林晓丹
LIN Xiaodan(Department of Laboratory Medicine, Fuzhou First Hospital Affiliated to Fujian Medical University, Fujian 350009, China)
出处
《中国老年保健医学》
2022年第2期89-91,共3页
Chinese Journal of Geriatric Care
关键词
老年高血压
认知功能障碍
炎症因子
相关性
elderly hypertension
cognitive dysfunction
inflammatory factors
correlation
