摘要
目的研究中西医结合治疗痛风性关节炎的疗效。方法方便选取2019年1月—2021年9月痛风性关节炎患者200例为研究对象进行回顾性分析,按照用药方法将患者分为对照组、观察组,对照组100例单一应用西医治疗,观察组100例结合应用中西医方法治疗,比较两组疗效、炎症因子、氧化应激因子及尿酸(UA)、红细胞沉降率(ESR)、糖类抗原724(CA724)水平差异。结果观察组治疗2周后UA、ESR、CA724水平均低于对照组,差异有统计学意义(t=11.599、13.196、17.367,P<0.05)。治疗2周后两组UA、ESR、CA724水平均低于治疗前,差异有统计学意义(P<0.05)。观察组治疗2周后白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)水平均低于对照组,且两组治疗2周后水平各指标均低于组内治疗前,差异有统计学意义(t=6.173、4.862、13.278、8.985、8.241,P<0.05)。观察组治疗2周后脂质过氧化物(LPO)、8-羟基脱氧鸟苷(8-OHdG)水平均低于对照组,总抗氧化能力(T-AOC)水平高于对照组,差异有统计学意义(t=15.417、28.111、17.803,P<0.05)。且两组治疗2周后LPO、8-OHdG水平均低于组内治疗前,T-AOC水平高于组内治疗前,差异有统计学意义(P<0.05)。观察组治疗2周后总有效率为90.00%,高于对照组总有效率80.00%,差异有统计学意义(χ^(2)=3.922,P<0.05)。结论中西医结合治疗痛风性关节炎的疗效明显优于单一西医治疗,能更有效降低血尿酸及血沉水平,控制炎症水平,改善氧化应激,获得更满意的总有效率,值得推广应用。
Objective To study the curative effect of integrated traditional Chinese and Western medicine in the treatment of gouty arthritis.Methods A retrospective analysis was performed on 200 patients with gouty arthritis from January 2019 to September 2021 were conveniently selected,and the patients were divided into control group and observation group according to the medication method.100 cases in the control group were treated with western medicine alone,and 100 cases in the observation group were treated with traditional Chinese and western medicine.The efficacy,inflammatory factors,oxidative stress factors,uric acid(UA),erythrocyte sedimentation rate(ESR),carbohydrate antigen 724(CA724)level difference.Results The levels of UA,ESR and CA724 in the observation group were lower than those in the control group after 2 weeks of treatment,the difference was statistically significant.The levels of UA,ESR and CA724 in the two groups after 2 weeks of treatment were lower than those before treatment,the difference was statistically significant(P<0.05).After 2 weeks of treatment in the observation group,interleukin-6(IL-6),interleukin-1β(IL-1β),interleukin-8(IL-8),C-reactive protein(CRP),tumor necrosis factor(TNF-α)levels were lower than those in the control group,the difference was statistically significant(P<0.05).The levels of each index in the two groups after 2 weeks of treatment were lower than those in the group before treatment,the difference was statistically significant(P<0.05).After 2 weeks of treatment,the levels of lipid peroxide(LPO)and 8-hydroxydeoxyguanosine(8-OHdG)in the observation group were lower than those in the control group,and the levels of total antioxidant capacity(T-AOC)were higher than those in the control group,the difference was statistically significant(t=15.417,28.111,17.803,P<0.05)After 2 weeks of treatment,the levels of LPO and 8-OHdG in the group were lower than those in the group before treatment,and the level of T-AOC was higher than that in the group before treatment,the difference w
作者
邹骁鸣
ZOU Xiaoming(Department of Endocrinology,Huishan Hospital of Traditional Chinese Medicine,Wuxi,Jiangsu Province,214173 China)
出处
《中外医疗》
2022年第8期194-198,共5页
China & Foreign Medical Treatment
关键词
中医
西医
治疗
痛风性关节炎
疗效
Traditional Chinese medicine
Western medicine
Treatment
Gouty arthritis
Curative effect
