摘要
目的探讨肝素钠对头孢唑啉钠和头孢他啶共存于腹膜透析液中稳定性的影响,为腹膜炎患者门诊治疗提供数据支持。方法采用高效液相色谱法测定在不同温度下肝素化或无肝素化的腹膜透析液中,24 h内头孢唑啉钠和头孢他啶的含量。同时测定药液的pH值,并观察其外观变化。结果头孢唑啉钠在肝素化或无肝素化4℃、25℃、37℃的腹膜透析液中,24 h内其含量均占原溶液的90%以上。头孢他啶在肝素化或无肝素化4℃和25℃的腹膜透析液中,24 h内其含量均占原溶液的90%以上;37℃时,6 h内其含量占原溶液的90%以上,24 h时,其含量占原溶液的90%以下。头孢唑啉钠含量的配对t检验结果P=0.9296,头孢他啶含量的配对Wilcoxon检验结果P=0.0798。所有实验条件下没有观察到药液的颜色改变和沉淀物生成,其pH值没有显著改变。结论肝素化对腹膜透析液中头孢唑啉钠和头孢他啶的含量变化无显著性影响。4℃和25℃条件下,头孢唑啉钠和头孢他啶存放24 h稳定,可方便药品预处理和保存;在37℃条件下,头孢他啶存放24 h,含量低于90%,会影响治疗效果。
Objective To investigate the stability of Cefazolin Sodium and Ceftazidime coexisting in heparinized peritoneal dialysis solution,thus to provide data to support outpatient treatment of peritonitis.Methods Cefazolin Sodium and Ceftazidime were injected into heparinized or nonheparinized dextrose 1.5%,dextrose 2.5%and dextrose 4.25%peritoneal dialysis solution,and then stored at 4℃in a refrigerator,25℃and 37℃in an incubator respectively.An aliquot was withdrawn immediately before(0 hour)or after 6 and 24 hours of storage.Each sample was analyzed in duplicate for the concentrations of Cefazolin Sodium and Ceftazidime by high performance liquid chromatography technique.Cefazolin Sodium and Ceftazidime were considered stable if they retained more than 90%of their initial concentration.Samples were also assessed for pH,color changes and precipitation after preparation.Results Cefazolin Sodium in heparinized or nonheparinized dextrose 1.5%,dextrose 2.5%and dextrose 4.25%peritoneal dialysis solution retained more than 90%of their initial concentration for 24 hours when stored at 4℃,25℃and 37℃.Ceftazidime in heparinized or nonheparinized dextrose 1.5%,dextrose 2.5%and dextrose 4.25%peritoneal dialysis solution retained more than 90%of their initial concentration for 24 hours when stored at 4℃and 25℃,who retained more than 90%of their initial concentration for 6 hours and less than 90%of their initial concentration for 24 hours when stored at 37℃.The concentrations of Cefazolin Sodium in the heparinized or nonheparinized peritoneal dialysis solution were compared by paired t test,and the P value was 0.9296.The concentrations of Ceftazidime were compared by paired Wilcoxon test,and the P value was 0.0798.No color change or precipitation was observed in any of the experimental conditions.The pH did not change substantially in any solution throughout the study.Conclusion The concentrations of Cefazolin Sodium and Ceftazidime are not affected significantly by heparinization.At 4℃and 25℃,Cefazolin Sodium
作者
林芸
陈霖
郭泽璜
唐小玲
LIN Yun;CHEN Lin;GUO Ze-huang;TANG Xiao-ling(Department of Pharmacy,Shantou Central Hospital,Guangdong Shantou 515031,China;Department of Nephrology,Shantou Central Hospital,Guangdong Shantou 515031,China)
出处
《临床药物治疗杂志》
2022年第5期63-67,共5页
Clinical Medication Journal
基金
2020年汕头市第四批医疗卫生科技计划项目(汕府科[2021]3号-51)
汕头市中心医院2018年科研培育计划项目(汕中心医[2019]3号-28)。
