摘要
放射性脑损伤(RBI)是头颈部恶性肿瘤放疗后的并发症之一,严重影响了患者的生活质量。RBI的病理生理机制目前尚不完全清楚,研究认为中枢神经系统(CNS)多种细胞参与其中,而星型胶质细胞作为CNS数量最多的胶质细胞,在维持CNS稳态及应对CNS损伤反应中发挥重要作用,本文就星形胶质细胞在RBI中的作用作一综述。
Radiation-induced brain injury(RBI)is one of the complications after radiotherapy for head and neck malignant tumors,which seriously affects the quality of life of patients.The pathophysiological mechanism of RBI is not completely clear.Current studies suggest that it is involved in a variety of cells in the central nervous system(CNS),whereas astrocyte,as the largest number of glial cells in the CNS,plays an important role in maintaining the CNS homeostasis and responding to CNS injury.In this article,the role of astrocytes in RBI was reviewed.
作者
朱文君
彭小红
李小钰
罗娜
唐雯华
伏敏
张圆圆
杨峰
周海婷
文粟
胡广原
Zhu Wenjun;Peng Xiaohong;Li Xiaoyu;Luo Na;Tang Wenhua;Fu Min;Zhang Yuanyuan;Yang Feng;Zhou Haiting;Wen Su(Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Oncology,Chengdu Seventh People's Hospital,Chengdu 610000,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2022年第6期589-593,共5页
Chinese Journal of Radiation Oncology
关键词
放射性脑损伤
星形胶质细胞
神经炎症
血管损伤
神经损伤
Radiation-induced brain injury
Astrocyte
Neuroinflammation
Vascular injury
Neuron damage
