摘要
目的分析和探讨血液净化治疗流行性出血热合并急性肾衰竭的疗效。方法15例流行性出血热合并急性肾衰竭患者为研究对象,均行血液净化治疗。观察患者治疗结果,治疗前及治疗后第3、10天的血常规、肾功能、肝功能指标。结果15例患者中,14例治愈出院,1例因多器官功能衰竭死亡。住院时间(17.50±8.11)d。治疗前、治疗后第3天、治疗后第10天,患者的白细胞计数(WBC)分别为(15.87±4.78)、(11.57±3.01)、(7.24±1.42)×10^(9)/L,中性粒细胞百分比(NEUT%)分别为(72.84±11.54)%、(67.53±10.88)%、(60.76±11.59)%,血小板计数(PLT)分别为(60.73±31.31)、(111.27±43.80)、(186.6±61.71)×10^(9)/L,C反应蛋白(CRP)分别为(50.89±22.39)、(26.93±18.19)、(4.48±3.16)mg/L。患者治疗前、治疗后第3天、治疗后第10天的WBC、NEUT%、PLT、CRP比较,差异具有统计学意义(P<0.05)。治疗后第3、10天,患者的WBC、CRP均低于治疗前,PLT均高于治疗前,差异具有统计学意义(P<0.05);治疗后第10天,患者的WBC、CRP低于治疗后第3天,PLT高于治疗后第3天,NEUT%低于治疗前,差异有统计学意义(P<0.05)。患者治疗后第3天与治疗后10天的NEUT%比较,差异无统计学意义(P>0.05)。患者治疗前、治疗后第3天、治疗后第10天的血尿素氮(BUN)、血肌酐(Cr)、胱抑素C(Cys-C)、β_(2)微球蛋白(β_(2)-M)比较,差异具有统计学意义(P<0.05)。治疗后第3、10天,患者的BUN、Cr、Cys-C、β_(2)-M均较治疗前降低,且治疗后第10天低于治疗后第3天,差异有统计学意义(P<0.05)。患者治疗前、治疗后第3天、治疗后第10天的血白蛋白(ALB)、谷草转氨酶(AST)比较,差异具有统计学意义(P<0.05)。治疗后第3、10天,患者ALB均较治疗前升高,AST均较治疗前降低,差异有统计学意义(P<0.05)。治疗后第10天,患者ALB高于治疗后第3天,AST低于治疗后第3天,谷丙转氨酶(ALT)低于治疗前,差异有统计学意义(P<0.05)。结论血液净化治疗流行
Objective To analyze and discuss the efficacy of blood purification treatment in 15 cases of epidemic hemorrhagic fever with acute renal failure.Methods 15 patients with epidemic hemorrhagic feverand acute renal failure were selected as the research subjects,and all of them received blood purification treatment.The therapeutic effect,blood routine,renal function and liver function indexes before treatment and 3 and 10 d after treatment were observed.Results Among the 15 patients,14 cases were cured and discharged,and 1 case died of multiple organ failure.The hospital stay was(17.50±8.11)d.Before treatment and 3 and 10 d after treatment,the patient's white blood cell count(WBC)were(15.87±4.78),(11.57±3.01),(7.24±1.42)×10^(9)/L,the neutrophil percentage(NEUT%)were(72.84±11.54)%,(67.53±10.88)%,(60.76±11.59)%,the platelet count(PLT)were(60.73±22.39),(111.27±43.80),(186.6±61.71)×10^(9)/L,and the C-reactive protein(CRP)were(50.89±31.31),(26.93±18.19),(4.48±3.16)mg/L.The differences were statistically significant(P<0.05)when comparing WBC,NEUT%,PLT,and CRP of patients before treatment,3 and 10 d after treatment.The patients'WBC and CRP at 3 and 10 d after treatment were lower than that before treatment,and the PLT were higher than that before treatment,and the differences were statistically significant(P<0.05).At 10 d after treatment,the patients'WBC and CRP was lower than that at 3 d after treatment,the PLT was higher than that at 3 d after treatment,and the NEUT%was lower than that before treatment.All the differences were statistically significant(P<0.05).There was no statistically significant difference in NEUT%between the 3 d after treatment and the 10 d after treatment(P>0.05).The differences in blood urea nitrogen(BUN),blood creatinine(Cr),cystatin C(Cys-C),andβ_(2)microglobulin(β_(2)-M)were statistically significant(P<0.05)when patients were compared before treatment,3 d after treatment,and 10 d after treatment.At 3 and 10 d after treatment,the BUN,Cr,Cys-C andβ_(2)-M of the patients were all d
作者
黄建溶
彭武建
陈烨
HUANG Jian-rong;PENG Wu-jian;CHEN Ye(Department of Nephrology,Shenzhen Third People’s Hospital,Shenzhen 518112,China)
出处
《中国实用医药》
2022年第8期15-18,共4页
China Practical Medicine
基金
广东省防治新型冠状病毒科技攻关专项(项目编号:2020B1111300004)。
关键词
流行性出血热
血液净化
急性肾衰竭
Epidemic hemorrhagic fever
Blood purification
Acute renal failure
