摘要
绝经后骨质疏松症以骨量减少、骨微结构发生改变为特征。中医学认为其与肝、脾、肾的生理功能密切相关,临床可见肝肾阴虚、脾肾阳虚、肝郁血虚、气滞血瘀等证型。治疗多从肝、脾、肾论治,兼顾行气活血化瘀,以脏腑气血阴阳调和为目的。现从肝、脾、肾的脏腑功能出发探讨绝经后骨质疏松的中医治疗,从分子层面总结中药、复方制剂治疗绝经后骨质疏松症的作用机制。分析中药及复方制剂中的主要活性成分,多靶点、多途径干预绝经后骨质疏松症相关信号通路的机制,为绝经后骨质疏松症治疗提供临床思路。
Postmenopausal osteoporosis is characterized by reduced bone mass and changes in bone microstructure,which is closely related to the physiological functions of liver,spleen and kidney in traditional Chinese medicine.Postmenopausal osteoporosis is mainly divided into four syndrome types such as Ganshen Yinxu syndrome,Pishen yangxu syndrome,Ganyu Xuexu syndrome,Qizhi Xueyu syndrome.Therefore treatment of postmenopausal osteoporosis mainly focuses on liver,spleen and kidney,taking into account Xingqi Huoxue Huayu,so as to achieve the purpose of Zangfu Yinyang Tiaohe.Discusses the traditional Chinese medicine(TCM)treatment of postmenopausal osteoporosis from the perspective of viscera functions of liver,spleen and kidney,and summarizes the mechanism of TCM and compound preparations in the treatment of postmenopausal osteoporosis from the molecular level.Based on the network pharmacology method,the multi-target and multi-pathway intervention mechanism of the main active ingredients in traditional Chinese medicine and compound preparations in postmenopausal osteoporosis related signal pathways was analyzed,to provide clinical ideas for the treatment of postmenopausal osteoporosis.
作者
周大标
吴冰心
阳越
吴钒
李志钢
ZHOU Dabiao;WU Bingxin;YANG Yue;WU Fan;LI Zhigang(The First Clinical College of Hubei University of Traditional Chinese Medicine,Wuhan 430065,China)
出处
《陕西中医》
CAS
2022年第6期752-754,766,共4页
Shaanxi Journal of Traditional Chinese Medicine
关键词
绝经后骨质疏松症
肝脾肾
淫羊藿
巴戟天
续断
Postmenopausal osteoporosis
Liver spleen and kidney
Epimedium
Medicinal indianmulberry root
Radix dipsaci
