摘要
各种原因所引起的心脏骤停是严重的公共卫生问题,提高心脏骤停患者的存活率是现代医学面临的严峻挑战之一。尽管近年来关于心肺复苏的研究取得很大进展,但患者在恢复自主循环后的预后并没有明显改善。心脏骤停可致凝血功能紊乱,引起一系列生理病理改变,严重影响患者预后,目前已有一些针对该病理变化的临床研究,通过常规及新型凝血功能监测手段探究其发生发展规律,且还有一些基础研究不断推理、验证此病理变化的分子层面机制。然而不同原因引起的心脏骤停,其凝血功能改变是存在差异的,在特殊环境下,如高原地区,具有低气压、低氧相对于平原地区具有特殊外部环境,使得高原地区机体凝血机制异常,其心肺复苏后凝血功能变化存在一定特异性,仍需大量研究去进一步探明其中变化影响,为心肺复苏的个体化治疗提供理论依据。本文就心肺复苏后患者凝血功能改变这一临床研究进展进行综述。
Cardiac arrest resulted from various causes is a serious public health problem.Improving the survival rate of patients with cardiac arrest has become one of the serious challenges in modern medicine.Despite the great advances in the study on cardiopulmonary resuscitation(CPR)in recent years,the prognosis of patients after the resumption of autonomic circulation has not improved significantly.Cardiac arrest can lead to coagulation disorders and a series of physiological and pathological alterations,which can seriously affect the prognosis of patients.Currently,some clinical studies have been conducted to investigate the development of these pathological alterations by means of conventional and novel coagulation function monitoring,and some basic studies have been conducted to deduce and verify the molecular-level mechanisms of these pathological alterations.However,there are differences in the alterations of coagulation function in cardiac arrest of different causes.For example,in special environments such as plateau areas,the coagulation mechanism of the body tends to be abnormal since air pressure and oxygen there are relatively lower than in plain areas.Besides,there will be certain specificity in the alterations of coagulation function after CPR,and a lot of studies are still required to further investigate the impact of these alterations,so as to provide a theoretical basis for the implementation of individualized CPR.This paper intends to review the advances in the clinical study on the alterations of coagulation function in patients after CPR.
作者
马增文
张斌
MA Zengwen;ZHANG Bin(Graduate School of Qinghai University,Xining 810016,China;Emergency Intensive Care Unit,Qinghai Provincial People's Hospital,Xining 810007,China)
出处
《中国现代医生》
2022年第14期194-196,共3页
China Modern Doctor
基金
青海省科技厅计划项目(2020-ZJ-771)。
关键词
心跳骤停
自主循环恢复
心跳骤停后综合征
凝血功能
Cardiac arrest
Resumption of autonomic circulation
Post-cardiac arrest syndrome
Coagulation function
