摘要
目的分析高血压脑出血(HICH)患者血清胱抑素C(CysC)、可溶性CD40L(sCD40L)水平及其临床检测价值。方法选取2016年6月~2019年1月笔者医院收治的95例HICH患者为HICH组,同期95例单纯高血压患者作为高血压组,同期60例健康体检者作为对照组。采用酶联免疫吸附法检测sCD40 L,胶乳免疫比浊法测定CysC。观察HICH组、高血压组及对照组患者血清CysC、sCD40L水平;并分析不同病情程度、不同预后情况HICH患者血清CysC、sCD40L水平差异,探讨HICH患者CysC、sCD40L水平与急性脑卒中评定表(NIHSS)评分及格拉斯哥预后评分(GOS)的相关性。结果HICH组、高血压组、对照组患者CysC、sCD40L水平比较,差异有统计学意义(F=32.116,P<0.001;F=302.524,P<0.001),HICH组血清CysC、sCD40L水平均明显高于对照组和高血压组(P<0.05)。不同病情程度3组CysC、sCD40L水平比较,差异有统计学意义(F=3.537,P=0.033;F=10.062,P=0.000),重度组CysC水平明显高于轻度组(P<0.05),sCD40L水平明显高于轻度组和中度组(P<0.05)。预后良好组HICH患者血清CysC、sCD40L水平明显低于预后不良组,差异有统计学意义(t=2.923,P=0.004;t=4.367,P<0.001)。HICH患者血清CysC、sCD40L水平与NIHSS评分呈正相关(r=0.430,P<0.000;r=0.375,P=0.002),与GOS评分呈负相关(r=-0.451,P<0.001;r=-0.503,P<0.001)。结论HICH患者CysC、sCD40L水平升高,检测其水平有助于帮助了解患者病情程度及预后判断。
Objective To analyze levels of serum cystatin C(CysC)and soluble CD40L(sCD40L)in patients with hypertensive intracerebral hemorrhage(HICH)and their clinical detection value.Methods A total of 95 HICH patients who were admitted to the hospital from June 2016 to January 2019 were enrolled as HICH group.A total of 95 hypertension patients in the same period were enrolled as hypertension group.A total of 60 healthy people who underwent physical examination in the same period were enrolled as control group.The sCD40L was detected by enzyme-linked immunosorbent assay.CysC was determined by latex immunoturbidimetry.The levels of serum CysC and sCD40L in HICH group,hypertensive group and control group were observed.The differences in levels of serum CysC and sCD40L levels among HICH patients with different severity and prognosis were analyzed.The correlation between CysC,sCD40L levels and National Institutes of Health Stroke Scale(NIHSS),Glasgow Outcome Scale(GOS)scores in HICH patients was explored.Results There were significant differences in levels of CysC and sCD40L among HICH group,hypertension group and control group(F=32.116,P<0.001.F=302.524,P<0.001).The levels of serum CysC and sCD40L in HICH group were significantly higher than those in control group and hypertension group(P<0.05).There were significant differences in levels of CysC and sCD40L of patients with different severity among the three groups(F=3.537,P=0.033.F=10.062,P<0.001).The CysC level in severe group was significantly higher than that in mild group(P<0.05),and level of sCD40L was significantly higher than that in mild group and moderate group(P<0.05).The levels of serum CysC and sCD40L in good prognosis group were significantly lower than those in poor prognosis group(t=2.923,P=0.004;t=4.367,P<0.001).The levels of serum CysC and sCD40L were positively correlated with NIHSS scores in HICH patients(r=0.430,P<0.001;r=0.375,P=0.002),while negatively correlated with GOS scores(r=-0.451,P<0.001;r=-0.503,P<0.001).Conclusion The levels of CysC and sCD40L
作者
吕成林
崔玉光
徐宝占
王永久
LV Chenglin;CUI Yuguang;XU Baozhan(Qingdao Eighth People′s Hospital,Shandong 266100,China)
出处
《医学研究杂志》
2022年第5期85-88,共4页
Journal of Medical Research
基金
青岛市医药科研指导计划项目(2019-WJZD107)。
