摘要
目的研究依帕司他联合硫辛酸治疗糖尿病周围神经病变的效果及对氧化应激指标、神经功能的影响。方法选取我院近两年收治的114例糖尿病周围神经病变患者进行对照研究,随即将其等分为对照组57例和研究组57例,比较氧化应激指标、多伦多临床评分系统(TCSS)、总症状积分(TSS)评分和疗效。结果两组治疗前超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物(GSH-Px)、TSS评分、TCSS评分差异较小(P>0.05),两组治疗后SOD、GSH-Px均升高,且研究组升高幅度大于对照组(P<0.05)。两组治疗后MDA、TSS评分、TCSS评分均降低,且研究组降低幅度大于对照组(P<0.05)。两组有效率比较(78.94%vs 96.49%),差异显著(t=8.143,P=0.004)。结论依帕司他联合硫辛酸治疗糖尿病周围神经病有助于抑制氧化应激,提高治疗效果,改善患者神经功能。
Objective To study the effect of epalrestat combined with lipoic acid in the treatment of diabetic peripheral neuropathy and its influence on oxidative stress indicators and nerve function.Methods 114 cases of diabetic peripheral neuropathy patients admitted to our hospital in the past two years were selected for a controlled study,and then they were divided into a control group of 57 cases and a study group of 57 cases,and the oxidative stress indicators,the Toronto Clinical Scoring System(TCSS),Total Symptom Score(TSS)score and efficacy were compared.Results The two groups had little difference in superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxide(GSH-Px),TSS score,and TCSS score before treatment(P>0.05).After treatment,SOD and GSH-Px in the group increased,and the increase in the study group was greater than that in the control group(P<0.05).The scores of MDA,TSS and TCSS of the two groups decreased after treatment,and the decrease of the study group was greater than that of the control group(P<0.05).The effective rate of the two groups was compared(78.94%VS.96.49%),and the difference was significant(t=8.143,P=0.004).Conclusion Epalrestat combined with lipoic acid in the treatment of diabetic peripheral neuropathy can help to inhibit oxidative stress,improve the therapeutic effect,and improve the patient’s nerve function.
作者
钦卓辉
司徒洁
林春梅
王金林
盛秋洁
邓奇
林瑞云
QIN Zhuo-hui;SITU Jie;LIN Chun-mei;WANG Jin-lin;SHENG Qiu-Jie;DENG Qi;LIN Rui-yun(Department of Occupational Diseases,Shenzhen Occupational Disease Prevention and Treatment Institute,Shenzhen 518020,Guangdong Province,China)
出处
《罕少疾病杂志》
2022年第6期105-106,112,共3页
Journal of Rare and Uncommon Diseases
