摘要
目的 了解河南省健康人群A群和C群脑膜炎奈瑟菌(Neisseria meningitis, Nm)抗体水平。方法 采用分层随机抽样方法于2019-2021年选取河南省8个县/市健康人群开展问卷调查和采集血清标本,采用酶联免疫吸附试验检测血清A群和C群Nm IgG抗体,分析抗体阳性率和中位数浓度(Median concentration, MC)。结果 共纳入5 073名调查对象,A群、C群Nm抗体总阳性率分别为53.83%、42.20%,MC分别为2.23μg/mL、1.49μg/mL。<1岁、1-2岁、3-4岁、5-6岁、7-14岁、15-19岁、≥20岁人群A群Nm抗体阳性率分别为29.79%、31.81%、58.00%、58.92%、66.39%、60.85%、70.99%(χ^(2)=468.58,P<0.001),C群Nm抗体阳性率分别为22.76%、29.18%、50.90%、43.15%、51.10%、45.98%、52.35%(χ^(2)=243.60,P<0.001)。结论 河南省健康人群尤其是低年龄儿童A群和C群Nm抗体处于较低水平;建议优化脑膜炎球菌疫苗接种策略和加强流行性脑脊髓膜炎防控工作。
Objective To explore antibody levels against group A and C Neisseria meningitis(Nm) in a healthy population of Henan province.Methods We used a stratified random sampling technique to select healthy individuals in 8 counties/cities of Henan during 2019-2021 for a questionnaire-based survey and collection of serum samples. We used an enzyme-linked immunosorbent assay to test for IgG antibodies against group A and group C Nm to determine seropositivity rates and median concentrations(MCs).Results Among the 5 073 subjects, overall positivity rates of group A and C Nm IgG antibodies were 53.83% and 42.20%, with MCs being 2.23μg/mL and 1.49μg/mL, respectively. Positivity rates for group A Nm IgG antibody among <1-, 1-2-, 3-4-, 5-6-, 7-14-, 15-19-, and ≥20-year-olds were 29.79%, 31.81%, 58.00%, 58.92%, 66.39%, 60.85%, and 70.99%(χ^(2)=468.58,P<0.001). Seropositivity rates for group C Nm IgG antibody were 22.76%, 29.18%, 50.90%, 43.15%, 51.10%, 45.98%, and 52.35%(χ^(2)=243.60,P<0.001).Conclusions Antibody levels against group A and C Nm were low in a healthy population of Henan, especially among young children. We suggest optimizing meningococcal vaccination strategies and strengthening meningococcal meningitis prevention and control.
作者
杨凯朝
杜冰会
姬艳芳
刘倩
孔江南
史鲁斌
李军
张肖肖
张延炀
Yang Kaichao;Du Binghui;Ji Yanfang;Liu Qian;Kong Jiangnan;Shi Lubin;Li Jun;Zhang Xiaoxiao;Zhang Yanyang(Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,Henan,China)
出处
《中国疫苗和免疫》
CSCD
北大核心
2022年第2期159-164,共6页
Chinese Journal of Vaccines and Immunization
