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改良CHOPE方案治疗继发中枢神经系统病变弥漫大B细胞淋巴瘤预后观察

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摘要 弥漫大B细胞淋巴瘤(DLBCL)属于非霍奇金淋巴细胞瘤的常见类型之一,临床大约有5%左右的患者会出现累及中枢神经系统的症状,包含诊断过程中以及疾病复发时,一旦患者出现累及中枢神经系统病变的症状,预后效果通常较差[1-3]。近几年,由于免疫治疗手段不断进步,使临床DLBCL患者的生存时间得到有效延长,但与此同时中枢神经出现侵犯的患者数量也随之增多。临床目前关于继发性中枢神经淋巴瘤(SCNL-DLBCL)的研究资料相对较少,因此较多的治疗方式只能借鉴原发性中枢神经系统淋巴瘤的治疗方案,再综合临床一线主治医师以及专家的方案进行制定[4]。由于患者存在血脑屏障,致使常规剂量的药物难以直接到达病灶,但加大剂量会导致患者发生毒副反应的风险升高,但对于这种情况目前尚未存在较好的解决方案[5]。
出处 《山西医药杂志》 CAS 2022年第7期797-799,共3页 Shanxi Medical Journal
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