摘要
细胞外囊泡是一种由细胞主动向外释放的膜性小囊泡,可装载DNA、RNA、脂质和蛋白质,是细胞间通信的重要调节者。细胞外囊泡由外泌体、微囊泡和凋亡小体组成,其中研究最全面的是外泌体。免疫细胞来源的细胞外囊泡通过调节免疫系统来增强或抑制免疫活动,在抗肿瘤过程中发挥重要作用。本文综述了细胞外囊泡的生物发生、提取与纯化和载药方法,重点介绍了免疫细胞来源的细胞外囊泡用于肿瘤治疗的研究进展。
Extracellular vesicles are membranous vesicles actively secreted by cells,which can carry DNA,RNA,lipids and proteins,and are important regulators of intercellular communication.Extracellular vesicles are composed of exosomes,microvesicles and apoptotic bodies,among which exosomes are the most comprehensively studied.Extracellular vesicles derived from immune cells enhance or inhibit immune activity by regulating the immune system and play an important role in the anti-tumor process.In this review,the biogenesis,extraction,purification and drug loading methods of extracellular vesicles were reviewed,with emphasis on the research progress of immune cell-derived extracellular vesicles used in tumor therapy.
作者
李爱雪
史彤
李亦秀
赵语南
姜良弟
顾永卫
刘继勇
LI Ai-xue;SHI Tong;LI Yi-xiu;ZHAO Yu-nan;JIANG Liang-di;GU Yong-wei;LIU Ji-yong(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355.China;Department of Pharmacy,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Shanghai Center of Biomedicine Development,Shanghai 201203,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2022年第8期746-751,共6页
Chinese Journal of New Drugs
基金
国家自然科学基金资助项目(82074272,81873011)
上海市优秀学术带头人计划资助项目(21XD1403400)。
关键词
细胞外囊泡
外泌体
免疫细胞
药物递送
肿瘤
extracellular vesicles
exosomes
immune cells
drug delivery
tumors
