摘要
目的初步探究肾虚型心因性勃起功能障碍与注意网络功能障碍的关系。方法2021年3月至2022年1月中国中医科学院西苑医院男科门诊26例肾虚型心因性勃起功能障碍患者为病例组。同时按照年龄、性别、受教育年限组间匹配的原则,选择24例男性健康者为对照组。对两组研究对象进行注意网络测试。结果与健康受试者相比,肾虚型心因性勃起功能障碍患者的平均反应时间和执行控制网络效率值明显降低,组间差异有统计学意义(P<0.05);而警觉网络效率值、定向网络效率值和平均正确率与正常对照组相比,差异无统计学意义(P>0.05)。其中执行控制网络效率值与肾阳虚积分呈正相关性(r=0.408,P=0.039)。多因素Logistic回归分析显示,执行控制网络效率值与肾虚型心因性勃起功能障碍有关(P<0.05)。结论肾虚型心因性勃起功能障碍患者的执行控制功能异常改变,这可能与注意控制功能相关脑区神经活动的改变有关,为中医从肾论治肾虚型心因性勃起功能障碍提供了现代科学依据。
Objective To investigate the relationship between psychogenic erectile dysfunction(pED)of kidney deficiency type(KD)and attention network dysfunction.Methods A total of 26 patients with pED of KD type and 24 were recruited from Xiyuan Hospital of China Academy of Chinese Medical Science from March 2021 to January 2022.And 24 healthy males were recruited as the control group according to the principle of matching between groups in terms of age,sex and years of education.Both study groups underwent attention network test(ANT).Results Compared with healthy subjects,the patients with pED of KD type showed significantly poorer efficiency on executive control network and overall mean reaction time(P<0.05).The alerting network efficiency,orienting network efficiency and mean correctness rates were not statistically significant compared to normal control subjects(P>0.05).Furthermore,efficiency on executive control network was positively associated with the scores of kidney yang deficiency(r=0.408,P=0.039).And the multi-factor Logistic regression analysis showed efficiency on executive control network was positively associated with pED of KD type(P<0.05).Conclusion Our findings suggested that patients with pED of KD type exhibited impairments of executive control network,which may be related to altered neural activities in brain regions associated with executive control functions.It provided a modern scientific basis for the treatment of psychogenic erectile dysfunction of kidney deficiency type by Chinese medicine theory of kidney.
作者
董麟瑞
晏斌
冯思同
宁艳哲
冯正田
贾竑晓
Dong Linrui;Yan Bin;Feng Sitong;Ning Yanzhe;Feng Zhengtian;Jia Hongxiao(The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China;Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China)
出处
《首都医科大学学报》
CAS
北大核心
2022年第3期393-397,共5页
Journal of Capital Medical University
基金
国家自然科学基金项目(81873398)
北京市医院管理中心临床医学发展专项经费资助(ZYLX202129)
北京医院管理中心登峰人才(DFL20191901)。
关键词
心因性勃起功能障碍
肾虚证
肾藏志理论
注意网络
psychogenic erectile dysfunction
kidney deficiency
the theory of kidney storing will
attention networks
