摘要
目的:对不同体重指数(BMI)2型糖尿病患者服用SGLT2抑制剂前后红细胞比容及一般临床资料比较,评估其治疗作用。方法:选取2019年8月-2021年6月门诊治疗的2型糖尿病患者61例,在原降糖方案的基础上,加用SGLT2抑制剂,观察治疗前、治疗后12周、24周时,红细胞比容和一般临床指标的变化。结果:与加用SGLT2抑制剂治疗前比较,体重指数(BMI)患者治疗后12周及24周时体重降低,差异有统计学意义(P<0.05)。肥胖前期患者治疗后12周及24周时体重、BMI、腰围、空腹血糖、糖化白蛋白、糖化血红蛋白降低,血红蛋白、红细胞比容升高,差异均有统计学意义(P<0.05)。肥胖患者治疗后12周及24周时体重、腰围、BMI、糖化白蛋白、糖化血红蛋白降低,血红蛋白、红细胞比容升高,差异均有统计学意义(P<0.05)。结论:SGLT2抑制剂的减重作用是与基线体重无关,基线BMI越高减重效果越明显,但同时会增加血红蛋白及红细胞比容。
Objective:To compare the hematocrit and general clinical data of type 2 diabetes patients with different body mass indexes(BMI)before and after treatment of SGLT2 inhibitor,and evaluate its therapeutic effect.Methods:A total of 61 patients with type 2 diabetes treated in the Outpatient Department from August 2019 to June 2021 were selected.Based on the original hypoglycemic regimen,SGLT2 inhibitor was given.The changes of hematocrit and general clinical indicators were observed before treatment,at 12 weeks and 24 weeks after treatment.Results:Compared with before treatment with SGLT2 inhibitor,the body weight of patients with normal BMI decreased at 12 weeks and 24 weeks after treatment,and the difference was statistically significant(P<0.05).The body weight,BMI,waist circumference,fasting blood glucose,glycated albumin and glycosylated hemoglobin decreased,while hemoglobin and hematocrit increased at 12 weeks and 24 weeks after treatment in pre-obesity patients,and the differences were all statistically significant(P<0.05).The body weight,waist circumference,BMI,glycated albumin and glycosylated hemoglobin decreased,while hemoglobin and hematocrit increased decreased at 12 weeks and 24 weeks after treatment in obese patients,and the differences were statistically significant(P<0.05).Conclusion:Weight loss effect of SGLT2 inhibitor is independent of baseline body weight.The higher baseline BMI is associated with more significant weight loss effect,and simultaneously hemoglobin and hematocrit are increased.
作者
董亚苒
王新芳
佘其美
刘改芬
Dong Ya-ran;Wang Xin-fang;She Qi-mei;Liu Gai-fen(General Practice Department,Shijingshan Teaching Hospital of Capital Medical University,Beijing 100040,China;Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China)
出处
《中国社区医师》
2022年第13期54-56,共3页
Chinese Community Doctors
