摘要
外泌体是一种由不同细胞分泌,存在于血液、尿液、脑脊液等不同体液中的细胞外囊泡,直径40~100 nm。因其富含多种生物活性的蛋白质、DNA、微小RNA等物质,是细胞间传递信号,相互作用的重要物质载体。较多研究表明不同细胞源性的外泌体能够促进细胞增殖分化,促使骨与血管再生,在骨组织工程中发挥着举足轻重的作用。笔者将对不同细胞源性的外泌体在骨质疏松症中的研究进展进行综述,以期为骨质疏松提供潜在的以细胞为基础的治疗新途径。
Exosomes are extracellular vesicles secreted by different cells and exist in different body fluids such as blood,urine.and cerebrospinal fluid,with a diameter of about 40-100 nm.Due to the rich in a variety of bioactive proteins,DNA,microRNA,and other substances,they are the important material carrier for signal transmission and interaction between cells.Numerous studies have shown that exosomes of different cell origins promote cell proliferation and differentiation,promote bone and blood vessel regeneration,and play an increasingly important role in bone tissue engineering.In this paper,the research progress of exosomes of different cell sources in osteoporosis is reviewed,in order to provide a new potential cell-based treatment for osteoporosis.
作者
张锐
柳海平
赵宁
李爱强
柴喜平
ZHANG Rui;LIU Haiping;ZHAO Ning;LI Aiqiang;CHAI Xiping(Gansu Provincial Hospital of TCM, Lanzhou 730050, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第5期744-748,共5页
Chinese Journal of Osteoporosis
基金
甘肃省中医药管理局科研课题(GZK-2019-2)
甘肃省科技计划项目(21JR1RA059)。
