摘要
Inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and dysbiosis.Extraintestinal manifestations can occur and affect several organs,including the liver and bile ducts,joints,skin,eyes,and less frequently,the heart,brain,and kidneys,increasing the risk of morbidity and mortality.These repercussions may be associated with the activity or severity of IBD.The present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations,aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.
出处
《BIOCELL》
SCIE
2021年第3期461-481,共21页
生物细胞（英文）
基金
supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq–Brazil)[435704/2018-4]
Fundação de AmparoàPesquisa do Estado de Alagoas(FAPEAL)/PPSUS/Ministério da Saúde(MS)[60030-000876/2016].
