摘要
近年来关于胃肠道癌症(GICs)的基础及临床研究取得了诸多进展,但GICs仍是导致全球癌症相关死亡的主要原因之一,给社会医疗带来巨大负担。作为天然药物中的单体成分之一,桦木酸(BA)因其较好的抗肿瘤特性而备受关注,文章从抑制GICs细胞增殖、抑制GICs细胞侵袭与转移、诱发GICs细胞凋亡、启动GICs细胞自噬、抑制GICs干细胞以及增敏GICs相关治疗药物6个方面对BA作用于GICs的已知机制进行综述。
Despite considerable advances have been made in basic and clinical studies,gastrointestinal cancers(GICs)remains one of the leading causes of cancer-related deaths worldwide,placing a heavy burden on social healthcare system.As one of the monomer components in natural medicine,betulinic acid(BA)has attracted wide attention because of its anti-tumor properties.This paper reviews the existing mechanisms of BA action on GICs from six aspects:inhibiting cell proliferation,inhibiting cell invasion and metastasis,inducing cell apoptosis,initiating cell autophagy,inhibiting stem cells,and sensitizing GICs-related therapeutic drugs.
作者
李怀玉
陈云
胡子毅
谭飞燕
刘培喆
邓慧灵
叶菁
LI Huai-yu;CHEN Yun;HU Zi-yi;TAN Fei-yan;LIU Pei-zhe;DENG Hui-ling;YE Jing(Graduate School,Jiangxi University of Chinese Medicine,Nanchang 330006,China;Emergency Department of Affiliated Hospital,Jiangxi University of Chinese Medicine,Nanchang 330006,China;Department of Internal Medicine of TCM,School of Clinical Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,China;Department of Gastroenterology,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)
出处
《南昌大学学报（医学版）》
2022年第2期87-93,共7页
Journal of Nanchang University：Medical Sciences
基金
江西省教育厅科学技术研究项目(GJJ201238)
江西省中医药中青年骨干人才培养计划(第一批)(赣中医药综合字[2020]9号,赣财社指[2020]59号)。
关键词
桦木酸
胃肠道癌症
细胞周期
增殖
凋亡
自噬
焦亡
肿瘤干细胞
betulinic acid
gastrointestinal cancers
cell cycle
proliferation
apoptosis
autophagy
pyroptosis
tumor stem cells
