摘要
信号转导和转录激活因子3(STAT3)是一种重要的转录因子,可被多种细胞因子和生长因子激活,在细胞生长、增殖和分化中发挥关键作用。研究表明,几乎所有的人类肝脏疾病和肝损伤动物模型中均存在STAT3过度激活的现象。通过抑制STAT3的激活可治疗急性肝损伤和肝纤维化,故STAT3抑制剂具有预防和治疗肝脏疾病的潜力。针对STAT3在肝损伤、肝炎、肝再生、肝纤维化和肝癌发生方面的研究进展作一综述。
Signal transduction and transcriptional activator 3(STAT3)is an important transcription factor that can be activated by many cytokines and growth factors.STAT3 plays a key role in cell growth,proliferation,and differentiation.It has been shown that hyperactivation of STAT3 exists in almost all animal models of liver injury and human liver diseases.Therefore,inhibition of STAT3 activation might become a promising strategy for prevention and treatment of acute liver injury and liver fibrosis.The research progress of STAT3 on liver injury,hepatitis,liver regeneration,liver fibrosis,and hepatocellular carcinoma were mainly discussed in this review.
作者
李婷婷
张俊平
LI Tingting;ZHANG Junping(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350100,China)
出处
《药学实践杂志》
CAS
2022年第3期208-212,280,共6页
Journal of Pharmaceutical Practice
基金
福建中医药大学高层次人才科研启动资金项目(X2019005)。
关键词
STAT3
肝损伤
肝纤维化
肝癌
STAT3
liver injury
liver fibrosis
hepatocellular carcinoma
