摘要
糖尿病肾病(DN)是糖尿病最常见微血管并发症之一。近年来,其发病率随着糖尿病总体患病率增加而不断升高,已经严重威胁并且影响到全球人类的健康。糖尿病肾病早期可见细胞外基质(ECM)过度沉积、肾小球基底膜逐渐增厚,从而致使肾小球系膜增殖,大量胶原沉积,晚期则表现为肾小球硬化以及肾脏纤维化(RF)。研究证实,肾脏纤维化是糖尿病肾病发展的关键病理过程,因此深入挖掘其发病机制并寻找安全有效的治疗方法成为当前研究热点。多项研究表明,中医中药治疗糖尿病肾脏纤维化具有明显优势,可通过调控转化生长因子-β(TGF-β)、分泌型糖蛋白(Wnt)/β-连环蛋白(β-catenin)、核转录因子-κB(NF-κB)、Notch、丝裂原活化蛋白激酶(MAPK)等多条信号通路来改善糖尿病肾脏纤维化。因而本文对其发病机制及其中医药治疗进行综述,以期为临床应用中医药治疗糖尿病肾脏纤维化提供参考。
Diabetic nephropathy(DN)is among the common microvascular complications of diabetes.In recent years,the incidence has been on the rise with the increase in prevalence of diabetes,threatening the health of human.The early stage of DN is characterized by excessive accumulation of extracellular matrix(ECM)and thickening of glomerular basement membrane which result in glomerular mesangial proliferation and massive collagen deposition.The late stage features glomerular sclerosis and renal fibrosis(RF).It has been confirmed that RF is the key pathological process for the development of DN.Therefore,it is the research focus to explore the pathogenesis and treatment methods of RF.It has been frequently verified that Chinese medicine is superior in the treatment of diabetic RF.It relieves diabetic RF by regulating transforming growth factor-β(TGF-β),secretory glycoprotein(Wnt)/β-catenin,nuclear factor-κB(NF-κB),Notch,mitogen-activated protein kinase(MAPK),and other signaling pathways.Therefore,this paper reviews the pathogenesis of diabetic RF and the treatment with Chinese medicine,which is expected to serve as a reference for clinical application of Chinese medicine in the treatment of diabetic RF.
作者
张圣英
尹长江
刘喜纲
杨坤宝
ZHANG Sheng-ying;YIN Chang-jiang;LIU Xi-gang;YANG Kun-bao(Chengde Medical University Institute of Traditional Chinese Medicine,Chengde 067000,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第11期275-282,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81804217)
承德医学院重点课题项目(201810)
承德医学院重大项目科研专项(KY2020006)。
关键词
糖尿病肾病
肾脏纤维化
发病机制
中医
中药
diabetic nephropathy
renal fibrosis
pathogenesis
traditional Chinese medicine
Chinese medicinal materials
