摘要
目的利用广东省脐带血造血干细胞库的临床应用数据,总结脐血在广东省内临床应用现况及其影响因素和治疗效果。方法对广东脐血库2007-2020年2132份临床应用脐血的应用疾病类型、脐血相关质量指标、应用后的植入情况、总生存率等数据进行统计分析。结果广东省脐血库公共库脐血目前治疗的主要疾病是血液病(87.3%)。脐血治疗的疾病类型与应用地区、性别、单个核细胞数、治疗类型和HLA配型情况差异均有统计学意义(P<0.01)。疾病类型、治疗类型、植入情况与第二年总生存率显著相关(P<0.01)。自体脐血临床应用中,除了血液病以外,应用最多的是神经再生方向;自体脐血治疗的疾病分类与性别、年龄、体重、TNC、冻存血量显著相关(P<0.01)。结论目前临床上脐血治疗的疾病与应用地区、性别等多个因素相关,以血液病治疗为主,并逐渐向神经再生等应用方向延伸,体现出脐血用于临床治疗的巨大潜力。
Objective To summarize the latest clinical application characteristics,influencing factors and therapeutic effects of umbilical cord blood(UCB)in Guangdong province,by using the clinical application data from Institution of Guangdong Cord Blood Bank.Methods The clinical application data on 2 132 cord blood samples from Institution of Guangdong Cord Blood Bank from 2007 to 2020 were statistically analyzed,including the types of diseases treated with umbilical cord blood,indexes of cord blood quality,implantation situation after application,and overall survival rate.Results The main disorders treated with UCB from the public banks in Guangdong were blood diseases(87.3%).There were significant differences in disease type,application area,sex,mononuclear cell number,treatment type and human leukocyte antigen(HLA)-matched condition(P<0.01).The overall survival rate in the second year was significantly correlated with disease type,treatment type and implantation status(P<0.01).In addition to hematologic diseases,autologous UCB was mostly used in nerve regeneration.Classification of the diseases treated with autologous cord blood was significantly correlated with gender,age,body weight,TNC and frozen blood volume(P<0.01).Conclusions The diseases clinically treated with UCB are related to multiple factors such as application area and gender.UCB is mainly used for blood diseases,and gradually extended to apply to the treatment of nerve regeneration,showing great potential of cord blood in clinical treatment.
作者
史聪颖
周海洋
魏伟
黄婉君
王颀
张复华
SHI Congying;ZHOU Haiyang;WEI Wei;HUANG Wanjun;WANG Qi;ZHANG Fuhua(Institution of Guangdong Cord Blood Bank,Guangzhou 510663,China;Guangzhou Municipality TianheNuoya Bio-engineering Co.,Ltd,Guangzhou 510663,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2022年第6期773-778,共6页
The Journal of Practical Medicine
基金
广州市科技计划项目(编号:201807010004)。
关键词
脐血
移植
输注
干细胞
cord blood
transplantation
infusion
stem cells
