摘要
目的 探讨血清D-二聚体(DD)、补体C3、清蛋白(Alb)、超氧化物歧化酶(SOD)水平与系统性红斑狼疮(SLE)患者病情活动度的关联性。方法 收集2016年8月至2017年2月于解放军总医院第一医学中心就诊的153例SLE患者(SLE组)及同期60例健康查体人员(对照组)的残余血清标本,检测血清DD、补体C3、Alb、SOD水平,比较SLE组和对照组血清相关指标水平变化。根据系统性红斑狼疮疾病活动指数(SLEDAI)评分将SLE患者分为轻度活动组(74例)和中重度活动组(79例),比较两组相关指标的变化。结果 SLE组血清DD水平高于对照组(P<0.05),补体C3、Alb,SOD水平低于对照组(P<0.05);SLE中重度活动组患者血清DD水平高于轻度活动组(P<0.05),补体C3、Alb、SOD水平低于轻度活动组(P<0.05)。多因素Logistic回归分析模型显示血清DD水平升高,补体C3、SOD水平降低是患者中重度活动度的独立危险因素(P<0.05),且预测模型曲线下面积(AUC)为0.910(95%CI 0.866~0.955,P<0.05),灵敏度为0.785,特异度为0.892。结论 血清DD、补体C3、Alb、SOD与SLE患者病情进展有关,且在患者病情活动度上有一定的预测价值。
Objective To investigate the correlation between serum D-dimer(DD),complement C3,albumin(Alb),superoxide dismutase(SOD)levels and disease activity in patients with systemic lupus erythematosus(SLE).Methods The residual serum samples of 153 SLE patients(SLE group)and 60 healthy persons(control group)who were treated in the First Medical Center of PLA General Hospital from August 2016 to February 2017 were collected.The levels of DD,complement C3,Alb and SOD in the samples were detected,and the changes of serum related indexes in the SLE group and the control group were compared.According to the systemic lupus erythematosus disease activity index(SLEDAI)score,patients with SLE were divided into mild activity group(74 cases)and moderate-severe activity group(79 cases),and the changes of serum-related indexes between the two groups were compared.Results The level of serum DD in the SLE group was higher than those in the control group(P<0.05),and the levels of complement C3,Alb and SOD were lower than those in the control group(P<0.05).The level of serum DD in the SLE moderate-severe activity group was higher than those in the mild activity group(P<0.05),and the levels of complement C3,Alb and SOD were lower than those in the mild activity group(P<0.05).Multivariate Logistic regression analysis model showed that increased serum DD levels,decreased complement C3 and SOD levels were independent risk factors for moderate to severe activity in patient(P<0.05),and the area under the curve(AUC)of the predictive model was 0.910(95%CI 0.866-0.955,P<0.05),the sensitivity was 0.785,and the specificity was 0.892.Conclusion Serum DD,complement C3,Alb and SOD are related to disease progression in patients with SLE,and have certain predictive value in terms of disease activity.
作者
王坤
赵玉荣
陈瑞
冀肖健
高艳红
燕文敬
WANG Kun;ZHAO Yurong;CHEN Rui;JI Xiaojian;GAO Yanhong;YAN Wenjing(Department of Clinical Laboratory,the Second Medical Center of PLA General Hospital/National Clinical Research Center for Geriatric Diseases,Beijing 100853,China;Department of Rheumatology and Immunology,the First Medical Center of PLA General Hospital,Beijing 100853,China;Department of Clinical Laboratory,the First Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《国际检验医学杂志》
CAS
2022年第10期1158-1161,共4页
International Journal of Laboratory Medicine
基金
国家重点研发计划项目子项目(2017YFF0205401)。
