摘要
目的探讨清热解毒方联合糖皮质激素治疗对老年重症肺炎(Severe pneumonia,SP)患者的疗效及对内皮功能及炎症活动的影响。方法选取2018年2月—2018年12月江苏省苏北人民医院收治的108例老年SP患者,按随机数字表法分为观察组和对照组,每组各54例。对照组在常规综合治疗的基础上给予糖皮质激素治疗,观察组在对照组基础上给予清热解毒方灌肠治疗,观察不同治疗方法对患者内皮功能和炎症活动的影响,并评价临床疗效。结果两组患者治疗后CRP、IL-6、IL-8、PCT水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后sE-selectin、vWF、ET-1、sFLT-1水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后APACHE-II、PSI评分及中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者病死率比较,差异无统计学差异(P>0.05)。观察组患者机械通气时间、ICU住院时间和住院时间均明显短于对照组,差异有统计学意义(P<0.05)。观察组患者治疗总有效率为87.04%(47/54)明显高于对照组70.37%(38/54),差异有统计学意义(P<0.05)。结论清热解毒方联合糖皮质激素能够显著改善老年SP患者血管内皮功能,控制炎症活动,从而改善相关症状,促进病情恢复。
Objective To investigate the effect of Qingre Jiedu Decoction combined with glucocorticoid on endothelial function and inflammatory activity in elderly patients with severe pneumonia(SP).Methods From February 2018 to December 2018,108 elderly patients with SP who were admitted to Subei People′s Hospital of Jiangsu Province were selected and divided into an observation group and a control group according to the random number table method,with 54 cases in each group.The control group was given glucocorticoid treatment on the basis of conventional comprehensive treatment,and the observation group was given Qingrejiedufang enema treatment on the basis of the control group.The effects of different treatment methods on endothelial function and inflammatory activity were observed,and the clinical efficacy was evaluated.Results After treatment,the levels of CRP,IL-6,IL-8,and PCT in the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the observation group was significantly lower than the control group,and the difference was statistically significant Significance(P<0.05).After treatment,the levels of sE-selectin,vWF,ET-1,and sFLT-1 in the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the observation group was significantly lower than the control group,and the difference was statistically significant Significance(P<0.05).After treatment,the APACHE-II,PSI and TCM syndrome scores in the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in mortality between the two groups(P>0.05).The mechanical ventilation time,ICU stay time and hospital stay time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of patients in the observation group was 87.04%(47/54),
作者
费燕
龚玉
陈敏
潘俊
FEI Yan;GONG Yu;CHEN Min;PAN Jun(Northern Jiangsu People′s Hospital,Yangzhou Jiangsu 225001)
出处
《世界中西医结合杂志》
2022年第2期294-298,共5页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省苏北人民医院基金项目(QN-2017-B022)。
关键词
重症肺炎
老年
清热解毒方
糖皮质激素
血管内皮功能
炎症活动
Severe Pneumonia
Elderly
Qingrejiedu Prescription
Glucocorticoid
Vascular Endothelial Function
Inflammatory Activity
