摘要
目的探讨子宫内膜异位症(Endometriosis,EM)痛经与原发性痛经(Primary dysmenorrhea,PD)用药的异同。方法筛选2016年1月1日—2021年1月1日期间近5年知网(CNKI)、维普(VIP)、万方所收录的相关文献,通过中医传承辅助平台(V3.0)进行数据挖掘,比较两者用药异同。结果共收集EM痛经处方92首,PD处方191首。EM痛经主要证型为肾虚血瘀,PD主要证型为寒凝血瘀、气滞血瘀。两者高频药物共22味一致。四气:EM痛经寒温并用,PD以温为主。五味均以甘、苦、辛为主。用药归经均以肝脾为主。根据关联规则算法,分别得到两者常用药对32、31个,其中14个相同;不同的药物组合中,EM痛经多以三棱、莪术为核心的药物组合。两者关联规则中当归-川芎均为高关联。核心方药两者均为香附四物汤加减,EM痛经在此基础上加上三棱、莪术等。结论EM痛经与PD治疗同中有异,均治以行气活血、温经止痛。但与PD相比,EM痛经用药重用破血行气之品,多用虫类药物,辅以补虚扶正之品。
Objective To comparison the law of TCM usage between endometriosis(EM)dysmenorrhea and primary dysmenorrhea(PD).Methods The literatures of traditional Chinese medicine treatment of EM dysmenorrhea or PD were collected from China national knowledge network(CNKI),Wanfang data knowledge service platform and VIP database in recent 5 years from January 1,2016 to January 1,2021.Data mining was carried out through the inheritance auxiliary system of traditional Chinese medicine(V3.0)to compare the law of TCM usage of them.Results A total of 92 prescriptions for EM dysmenorrhea and 191 prescriptions for PD were collected.Kidney deficiency blood stasis was the most common TCM Syndrome of EM dysmenorrhea,and cold coagulation blood stasis and Qi stagnation and blood stasis were the most common in PD.A total of 22 high-frequency herbs were consistent between the two.The four natures of PD is mainly warm,whereas the cold and the heat herbs are unified in EM dysmenorrhea.Traditional Chinese medicine is mainly pungent,sweet and bitter.And the most common meridian is the liver,spleen.Through the analysis of association rules,31 and 32 common herb pairs were obtained,among which 14 were the same.Among the different drug combinations,the herb pairs of Sanleng(Rhizoma Sparganii)and Ezhu(Rhizoma Curcumae)is more used for EM.The results of the association rule analysis both showed that Danggui(Radix Angelicae Sinensis)-Chuanxiong(Rhizoma Ligustici Chuanxiong)were highly associated.Both core prescriptions are based on Xiangfu Siwu Decoction,EM dysmenorrhea combined with Sanleng(Rhizoma Sparganii)and Ezhu(Rhizoma Curcumae),etc.Conclusion The law of TCM usage of them are identical though with minor differences.The common treatment is to promote Qi and blood circulation,warm meridians and relieve pain.By contrast in the treatment of EM dysmenorrhea,traditional Chinese medicine mainly use blood breaking and qi activating medicine and insect medicines,and supplement by the Chinese medicine to strengthen the body.
作者
鲍美如
时光
张永嘉
孙文杰
赵瑞华
BAO Mei-ru;SHI Guang;ZHANG Yong-jia;SUN Wen-jie;ZHAO Rui-hua(Beijing University of Chinese Medicine,Beijing 100029;Guang′anmen Hospital,China Academy of Traditional Chinese Medicine,Beijing 100053)
出处
《世界中西医结合杂志》
2022年第2期243-248,共6页
World Journal of Integrated Traditional and Western Medicine
基金
首都卫生发展科研专项项目(首发2018-1-4151)。
关键词
痛经
原发性痛经
子宫内膜异位症
用药规律
Dysmenorrhea
Primary Dysmenorrhea
Endometriosis
Medication Rules
