摘要
目的 探讨养心定悸胶囊联合皮部针刺治疗冠心病快速型心律失常的疗效,并观察其对患者心率变异性(Heart rate variability, HRV)、血清炎性因子的影响。方法 选取2018年4月—2021年4月期间黔东南州中医医院收治的冠心病合并快速型心律失常患者108例,按随机数字表法分为对照组和治疗组,各54例。对照组给予常规西药治疗,在此基础上,治疗组给予养心定悸胶囊口服联合皮部针刺。两组患者均治疗4周后,观察比较两组患者临床疗效,心功能[左心室舒张末期内径(Left ventricular end-diastolic dimension, LVEDD)、左心室射血分数(Left ventricular ejective fraction, LVEF)、6 min步行试验(6-minute walk test, 6MWT)],HRV相关指标[全程相邻RR间期间差平方根(RMSSD)、心跳百分比(PNN50)、正常RR间期标准差(SDNN)、5 min均值标准差(SDANN)],血清炎性因子水平[血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein, CRP)水平]及不良反应情况。结果 治疗后治疗组总有效率为85.19%(46/54)高于对照组67.92%(36/53),差异有统计学意义(P<0.05)。治疗后两组患者LVEDD水平均低于治疗前,LVEF、6MWT水平均高于治疗前,差异有统计学意义(P<0.05);且治疗组LVEDD水平低于对照组,LVEF、6MWT水平均高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者RMSSD、PNN50、SDNN、SDANN指标均高于治疗前,差异有统计学意义(P<0.05);且治疗组均高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清TNF-α、IL-6、CRP水平均低于治疗前,差异有统计学意义(P<0.05);且治疗组均低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均出现较轻微不良反应,不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 养心定悸胶囊联合皮部针刺治疗冠心病快速型心律失常能够有效改善患者临床症状、HRV、血清炎性因子�
Objective To explore the efficacy of Yangxin Dingji Capsules combined with skin acupuncture in the treatment of coronary heart disease(CHD)-induced tachyarrhythmia and observe its influence on heart rate variability(HRV)and serum inflammatory factors.Methods A total of 108 patients with CHD-induced tachyarrhythmia admitted to Qiandongnan Prefecture Traditional Chinese Medicine Hospital from April 2018 to April 2021 were enrolled and divided into a control group(54)and a treatment group(54)according to a random number table.All patientswere treated with conventional western medicine, while those in the treatment group received additional Yangxin Dingji Capsules combined with skin acupuncture.After four weeks of treatment, the clinical efficacies, cardiac functions[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and 6-minute walk test(6 MWT)],HRV-related indicators[root mean square of successive differences between normal heartbeats(RMSSD),proportion of NN50 divided by the total number of NN intervals(PNN50),standard deviation of NN intervals(SDNN),and standard deviation of the average NNintervals for each of the 5 min segments during a 24 h recording(SDANN)],and serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and C-reactive protein(CRP)]of the two groups were compared, and the incidence of adverse events was recorded.Results After treatment, the total effective rate of the treatment group was 85.19%(46/54),higher than 67.92%(36/53)of the control group(P<0.05).After treatment, LVEDD decreased, and LVEF and 6 MWT increased in both groups(P<0.05).LVEDD of the treatment group was lower and LVEF and 6 MWT were higher than those in the control group(P<0.05).After treatment, RMSSD,PNN50,SDNN,and SDANN of the two groups were higher than those before treatment(P<0.05),and the treatment group was higher than the control group(P<0.05).The post-treatment serum levels of TNF-α,IL-6,and CRP were lower than those before treatment in both groups(P<0.05
作者
沈文
欧文武
杨正荣
SHEN Wen;OU Wen-wu;YANG Zheng-rong(Qiandongnan Prefecture Traditional Chinese Medicine Hospital,Kaili Guizhou556000)
出处
《世界中西医结合杂志》
2022年第3期556-560,共5页
World Journal of Integrated Traditional and Western Medicine
基金
贵州省中医药管理局科研计划项目(2019MC265)。
关键词
冠心病
心律失常
养心定悸胶囊
皮部针刺
心率变异性
炎性因子
Coronary Heart Disease
Tachyarrhythmia
Yangxin Dingji Capsules
Skin Acupuncture
Heart Rate Variability
Inflammatory Factors
