摘要
脾失健运是指脾脏运化失常,使得水谷之精失于布散,水液代谢障碍从而痰湿内蕴,脾失健运是中医体质的重要病机,但是目前对脾失健运的微观机制认识尚不清晰。肠道屏障以不同形式共同将肠道内外环境隔离,具有阻止致病病原体侵袭的功能。肠道屏障受损则会引起机体炎症反应及胰岛素抵抗,导致糖脂代谢障碍进而导致痰湿体质易发代谢性疾病,可为脾失健运的内在机制提供新的科学阐释。另外,中医药可通过调节肠道菌群等方式改善肠道屏障功能,减轻慢性炎症状态和胰岛素抵抗,从而改善代谢异常状态,肠道屏障可作为痰湿体质调体的一个新的靶点。从肠道屏障功能受损的角度来阐释痰湿体质脾失健运的微观机制,可为基于肠道屏障功能的痰湿体质临床调体提供现代科学依据,从而进一步指导临床实践。
Spleen failing to transport could result in abnormal distribution of water and food and disorder of body fluid metabolism, thus producing pathological phlegm and dampness accumulation. It is also an important pathogenesis of Chinese medicine constitution. Current understanding of its microscopic mechanism is still limited. The intestinal barrier isolates the internal and external environment of the intestinal tract in different forms, and has the function of preventing invasion of pathogenic agents. The damage of intestinal barrier function will cause inflammation and insulin resistance, which will lead to glucolipid metabolism disorders and phlegm-dampness constitution susceptible to multiple metabolic diseases. From this perspective, it can provide a new scientific explanation for the internal mechanism of spleen failing to transport. In addition, Chinese herbal medicine could improve the intestinal barrier function by regulating intestinal flora, reduce chronic inflammation and insulin resistance, thereby improving metabolic abnormalities, intestinal barrier function can serve as a new target for regulating phlegm-dampness constitution. This study aimed to reveal the microscopic mechanism of spleen’s failing to transport in phlegm-dampness constitution from the perspective of impaired intestinal barrier function. It could provide scientific basis for rectifying phlegm-dampness constitution which could be of profound significance for the clinical practice of Chinese medicine.
作者
郭文茜
万瑾毅
姚海强
GUO Wenqian;WAN Jinyi;YAO Haiqiang(Beijing University of Chinese Medicine,Beijing China,100029)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2022年第4期393-397,共5页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金项目(No.81973714,No.81803970)
中华中医药学会“青年人才托举工程”项目(No.CACM-2019-QNRC2-A01)
中央高校基本科研业务费专项(No.2020-JYB-XJSJJ-003)
北京中医药大学“青年科学家培育计划”项目(No.2019-05-01)。
关键词
中医体质
痰湿体质
肠道屏障
脾失健运
代谢紊乱
Chinese medicine constitution
phlegm-dampness constitution
intestinal barrier function
spleen failing in transportation
metabolic disorders
