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基于中医体质学原理探析肺部菌群对过敏性哮喘的调控作用 被引量:5

Analyzing the regulatory effect of pulmonary flora on allergic asthma based on the principles of TCM constitution
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摘要 中医体质学以其四大基本原理为其坚固的理论基石,具体阐释了人体体质的形成、特征、变化规律及人体体质的生理病理特征。过敏体质是中医体质学研究中一种重要的偏颇体质,是多种过敏性疾病发生的背景和土壤。共生微生物对于宿主免疫稳态的建立及免疫系统的发育成熟具有重大意义,并与过敏性疾病的发生发展明确相关。新近研究证实肺部菌群对过敏性哮喘的发生发展有直接或间接的调控作用,其作用的模式和规律与中医体质学原理相符。从中医体质学角度阐释两者的相关性,从体质学角度为过敏性哮喘的临床诊疗拓宽新思路。 The four basic principles as the theoretical cornerstones of TCM constitution theory elaborate the formation, characteristics, and changes of the body constitutions, as well as the physiological and pathological characteristics of these constitutions. Allergic constitution is an important biased TCM constitution, which is an underlying condition for various allergic diseases. Symbiotic microbiome is of great significance to the establishment of immune homeostasis and the development and maturation of the immune system, and clearly related to the development of allergic diseases. The lung microbiome could regulate the occurrence and development of allergic asthma directly or indirectly, which is consistent with the basic principles of TCM constitution. The explanation from the perspective of TCM constitution theory provides a view to broadening the ideas of clinical diagnosis and treatment of allergic asthma.
作者 王一 王琦 孟翔鹤 王济 WANG Yi;WANG Qi;MENG Xianghe;WANG Ji(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;National Institute of TCM constitution and Prevention Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处 《北京中医药大学学报》 CAS CSCD 北大核心 2022年第4期387-392,共6页 Journal of Beijing University of Traditional Chinese Medicine
基金 国家自然科学基金面上项目(No.81973715,No.82174243) 国家中医药传承创新团队项目(No.ZYYCXTD-C-202001)。
关键词 过敏性哮喘 中医体质学 肺部菌群 过敏体质 肠道菌群 肠-肺轴 共生微生物 allergic asthma TCM constitution lung microbiota allergic constitution gut microbiome gut-lung axis microbiome
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