摘要
目的分析与老年癌症患者认知障碍的发生有关的影响因素。方法使用简易精神状态检查(Mini-Mental State Examination,MMSE)量表和蒙特利尔认知评估(Montreal Cognitive Assessment,MoCA)量表等精神心理测试方法,对132例老年癌症患者进行认知障碍的评估,根据认知障碍的有无将其分为观察组(67例)和对照组(65例),比较分析老年癌症合并认知障碍的相关因素。结果单因素分析显示,年龄较大、接受过全身麻醉下手术、接受过化疗及靶向治疗及存在抑郁、焦虑状态的患者更易出现认知障碍(P<0.05);多因素分析显示,年龄、抑郁、全身麻醉下手术史、化疗及靶向治疗史是老年癌症患者发生认知障碍的主要影响因素(P<0.05)。结论认知障碍是老年癌症患者常见的中枢神经系统疾病,临床中应密切关注年龄、全身麻醉下手术史、化疗和靶向治疗史以及焦虑、抑郁等因素对发生认知障碍的影响,做好预防和早诊早治。
Objective To analyze the influencing factors of cognitive impairment in elderly cancer patients.Method A total of 132 elderly cancer patients were evaluated for cognitive impairment using the Mini-Mental State Examination(MMSE)scale and the Montreal Cognitive Assessment(MoCA)scale.Based on the cognitive impairment,they were divided into the observation group(67 cases)and control group(65 cases)and factors associated with cognitive impairment in elder cancer patients were compared and analyzed.Result Univariate analysis showed that patients who were older,had undergone surgery with general anesthesia,had received chemotherapy and targeted therapy and had depression and anxiety states were more likely to develop cognitive impairment(P<0.05).Multivariate analysis showed that age,surgery with general anesthesia,chemotherapy and targeted therapy,depression were the main influencing factors of cognitive impairment in patients with elderly cancer.Conclusion Cognitive impairment is a common central nervous system disorder in elderly cancer patients.In clinical practice,we should pay close attention to the influence of age,history of general anesthesia,history of chemotherapy and targeted therapy,anxiety,depression and other factors on cognition,and make good prevention,early diagnosis and treatment.
作者
隋晨光
周雅静
李冬海
孙凯
Sui Chenguang;Zhou Yajing;Li Donghai;Sun Kai(Department of Oncology,Beijing Fengtai You'anmen Hospital,Beijing 100069,China;Department of Burn and Plastic Surgery,Beijing Fengtai You'anmen Hospital,Beijing 100069,China)
出处
《中国医学前沿杂志（电子版）》
2022年第5期47-50,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
老年
癌症
认知障碍
Elderly
Cancer
Cognitive impairment
