甘露醇、单唾液酸神经节苷脂联合应用治疗脑出血致脑水肿的疗效及对神经功能的影响被引量：2

Efficacy of Combined Application of Mannitol and Monosialoganglioside in the Treatment of Cerebral Edema Caused by Cerebral Hemorrhage and its Effect on Neurological Function

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摘要目的:探究联合应用甘露醇、单唾液酸神经节苷脂治疗脑出血致脑水肿的疗效及对神经功能的影响。方法:选取2019年1月—2020年1月开封东原康复医院收治的90例脑出血致脑水肿患者作为研究对象,随机分为观察组46例(采用甘露醇+单唾液酸神经节苷脂治疗)和对照组44例(采用甘露醇治疗),比较两组患者治疗前后的ADL评分、NIHSS评分、水肿、血肿面积、不良反应和生活质量评分。结果:(1)治疗后,两组患者ADL评分、NIHSS评分、水肿面积和血肿面积均有所改善,且观察组更优。(2)治疗后,观察组不良反应6.52%显著低于对照组18.18%,差异无统计学意义(χ^(2)=2.850,P>0.05)。(3)治疗后,观察组的各项生活质量评分显著高于对照组,差异有统计学意义(t=13.043、11.772、17.353、14.787,P<0.05)。结论:对脑出血并发脑水肿患者,运用甘露醇+单唾液酸神经节苷脂治疗,可明显改善病人的神经功能,改善水肿和血肿情况,降低不良反应发生率,提升预后与转归水平,值得参考。 Objective:To explore the efficacy of combined application of mannitol and monsialic acid ganglioside in the treatment of cerebral edema caused by cerebral hemorrhage and its influence on nerve function.Methods:A total of 90 patients with cerebral edema caused by cerebral hemorrhage admitted to the hospital from January 2019 to January 2020 were selected and randomly divided into observation group(46 cases,treated with mannitol+monosialoganglioside)and control group(44 cases,treated with mannitol).The ADL score,NIHSS score,edema,hematoma area,adverse reactions and quality of life scores were compared between the two groups before and after treatment.Results:(1)After treatment,the ADL score,NIHSS score,edema area and hematoma area of the two groups improved,and the observation group was better.(2)After treatment,the adverse reaction rate in the observation group was 6.52%,which was significantly lower than 18.18% in the control group,the difference was not statistically significant(χ^(2)=2.850,P>0.05).(3)After treatment,the quality of life scores of the observation group were significantly higher than those of the control group,the difference was statistically significant(t=13.043,11.772,17.353,14.787,P<0.05).Conclusion:For patients with cerebral hemorrhage complicated by cerebral edema,the use of mannitol+monosialoganglioside therapy can significantly improve the patient’s neurological function,improve edema and hematoma,reduce the incidence of adverse reactions,and improve the prognosis and outcome level,which is worthy of reference.

作者程亚萍 CHENG Ya-ping(Kaifeng Dongyuan Rehabilitation Hospital,Kaifeng,Henan,475400,China)

机构地区开封东原康复医院

出处《黑龙江医学》 2022年第8期999-1001,共3页 Heilongjiang Medical Journal

关键词甘露醇单唾液酸神经节苷脂脑出血脑水肿神经功能 Mannitol Monsialic acid ganglioside Cerebral hemorrhage Brain edema Nerve function

分类号 R722.151 [医药卫生—儿科]