摘要
黄精作为我国传统的药食同源性中药具有较高的药用价值。黄精含有多糖、甾体皂苷、黄酮、木脂素、氨基酸和生物碱等化学成分,可通过多种信号通路发挥抑制肿瘤、免疫调节、调控血糖血脂、抗氧化以及抗炎等效应,因此,可用于阿尔茨海默病(AD)、糖尿病、动脉粥样硬化等疾病的临床治疗。未来全面深入了解黄精防治AD相关认知功能障碍的机制有助于进一步探索AD的病理过程,从而为AD患者的早期诊断和治疗提供新思路。
Polygonatum sibiricum,as a traditional Chinese medicine with food and drug homology,has high medicinal value.Polygonatum sibiricum contains polysaccharides,steroidal saponins,flavonoids,lignans,amino acids and alkaloids and other chemical components,which can exert anti-tumor,immunomodulatory,blood sugar and lipid regulation,antioxidant and anti-inflammatory effects through a variety of signaling pathways,and can be used in the clinical treatment of Alzheimer's disease(AD),diabetes,atherosclerosis and other diseases.Therefore,a comprehensive understanding of the mechanism of the effect of Polygonatum sibiricum on AD related cognitive dysfunction can help to further explore the pathological process of AD,with a view to providing new ideas for the early diagnosis and treatment of the AD patients.
作者
黄家鹏
赵健
赵璇
赵福红
宫铭海
周忠光
HUANG Jiapeng;ZHAO Jian;ZHAO Xuan;ZHAO Fuhong;GONG Minghai;ZHOU Zhongguang(School of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department One of Acupuncture,Hanan Branch,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;School of Sports Science,Shanghai University of Sport,Shanghai 200438,China)
出处
《医学综述》
CAS
2022年第8期1606-1612,共7页
Medical Recapitulate
关键词
阿尔茨海默病
黄精
认知功能
药理作用
Alzheimer's disease
Polygonatum sibiricum
Cognitive function
Pharmacological effects
