摘要
以1,2丙二醇、肉豆蔻酸异丙酯(IPM)、聚氧乙烯氢化蓖麻油(PEG-40)为原料包裹氢化可的松,利用正交试验筛选出最佳的制备条件,对已载药自微乳进行红外光谱分析以及透皮实验,测定载药自微乳的生物利用度。结果表明,IPM∶PEG-40∶1,2丙二醇为20%∶53%∶27%的氢化可的松自微乳具有较好的透皮效率。
The self-microemulsifying drug delivery system is a new drug-carrying preparation composed of oil phase,emulsifier and co-emulsifier;.1,2 propylene glycol,isopropyl myristate(IPM),polyoxyethylene hydrogenated castor oil(PEG-40)as raw materials wrapped in hydrocortisone,the use of univariate orthogonal experiments to screen out the best preparation conditions,the drug has been loaded from microemulsion stability investigation,Fourier infrared spectroscopy analysis and transdermal experimental determination,to determine the bioavailability of drug-carrying self-microemulsion.The results show that 1%hydrocortisone self-microemulsion with drug carrier has good transdermal efficiency.
作者
陈彩怡
刘雅倩
吴湛霞
姚慧琦
康信煌
邓春梅
吴育廉
张国光
Chen Caiyi;LIU Yaqian;WU Zhanxia;Yao Huiqi;Kang Xinhuang;Deng Chunmei;Wu Yulian;Zhang Guoguang(College of Chemistry and Environment,Guangdong Ocean University,Guangdong Zhanjiang 524088)
出处
《石化技术》
CAS
2022年第4期56-57,38,共3页
Petrochemical Industry Technology
基金
海洋生物材料研究重点实验室(No.A15445)
海洋资源化学综合利用研究重点实验室(No.A14457)
广东海洋大学创新强校项目(No.GDOU2017052502)。
关键词
氢化可的松
自微乳
经皮给药
聚氧乙烯氢化蓖麻油
FRANZ扩散池
Hydrocortisone
Self-microemulsion
Percutaneous administration
Polyoxyethylene hydrogenated castor oil
Franz diffusion pool
