摘要
目的探讨胃食管反流病(GERD)合并抑郁患者的食管动力指标、pH值监测情况及其临床意义。方法选取GERD患者100例,采用抑郁自评量表(SDS)评估患者抑郁情况,分析抑郁和无抑郁患者在食管动力、pH值监测指标存在的差异。结果100例GERD患者中,合并抑郁的患者47例;GERD合并抑郁患者中反流性食管炎(RE,33例)为70.21%,明显高于无抑郁的患者(P<0.05);GERD合并抑郁患者食管下括约肌压力(LESP)和远端收缩积分(DCI)分别为(7.20±0.98)mmHg和(350.24±65.59)mmHg·s·cm,明显低于无抑郁患者(P<0.05),而食管体部收缩前沿速度(CFV)、pH<4的总时间比例、立位pH<4的时间比例、pH<4反流次数、pH<4大于5 min反流次数和DeMeester评分分别为(4.11±0.98)cm/s、(20.02±5.54)%、(7.81±0.62)%、(56.60±6.30)次、(10.40±2.10)次和(17.50±1.30)分,明显高于无抑郁患者(P<0.05);合并抑郁患者中,RE组患者LESP为(6.99±1.01)mmHg,明显低于非糜烂性反流病(NERD)患者(P<0.05),而pH<4的总时间比例、pH<4大于5 min反流次数、DeMeester评分和SDS评分分别为(21.18±4.12)%、(10.84±2.04)次、(18.25±1.22)分和(67.60±5.44)分,明显高于NERD患者(P<0.05);SDS评分与LESP呈负相关(P<0.05);SDS评分与pH<4的总时间比例、pH<4反流次数、DeMeester评分呈正相关(P<0.05)。结论GERD合并抑郁有较高的比例,合并抑郁的患者食管动力减弱,酸反流严重,抑郁程度可能与患者食管动力、pH有关;在不同GERD类型中,RE合并抑郁患者食管动力明显减弱,酸反流严重。
Objective To investigate the esophageal motility,pH and clinical significance in patients with gastroesophageal reflux disease(GERD)complicated with depression.Methods 100 GERD patients were selected,the self rating Depression Scale(SDS)was used to evaluate the depression of patients,the differences of esophageal motility and pH between depressed and non-depressed patients were analyzed.Results Among 100 GERD patients,47 patients with depression.The proportion of reflux esophagitis(RE)in GERD patients with depression was 70.21%,which was significantly higher than that in patients without depression(P<0.05).The lower esophageal sphincter pressure(LESP)and Distal contract integral(DCI)in GERD patients with depression were(7.20±0.98)mmHg and(350.24±65.59)mmHg·s·cm,respectively,which were significantly lower than those patients without depression(P<0.05),the Esophageal body contract frontal velocity(CFV)total time ratio of pH<4,the time ratio of standing pH<4,the reflux times of pH<4,the reflux times of pH<4 greater than 5 min and Demeester score were(4.11±0.98)cm/s,(20.02±5.54)%,(7.81±0.62)%,(56.60±6.30),(10.40±2.10)and(17.50±1.30)respectively,which were significantly higher than those without depression(P<0.05).In patients with depression,the LESP of RE patients were(6.99±1.01)mmHg,respectively,which were significantly lower than NERD patients(P<0.05),while the total time proportion of pH<4,the reflux times of pH<4 greater than 5 min,DeMeester score and SDS score were(21.18±4.12)%,(10.84±2.04),(18.25±1.22)and(67.60±5.44)respectively,which were significantly higher than NERD patients(P<0.05).SDS score was negatively correlated with LESP(P<0.05).SDS score was positively correlated with the total time ratio of pH<4,the reflux times of pH<4 and DeMeester score(P<0.05).Conclusion GERD complicated with depression has a high proportion.Esophageal motility is weakened and acid reflux is serious in patients with depression.The degree of depression may be related to esophageal motility and pH;In different GERD
作者
郭虹
杨翠红
刘晓敏
姚曙徽
GUO Hong;YANG Cui-hong;LIU Xiao-min;YAO Shu-hui(Department of Gastroenterology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471023,Henan,China)
出处
《广东医学》
CAS
2022年第4期503-506,共4页
Guangdong Medical Journal
基金
河南省科技厅重点科技攻关项目(182102310302)。
关键词
胃食管反流病
抑郁
食管动力
PH值
gastroesophageal reflux disease
depression
esophageal motility
pH
