摘要
目的探讨万古霉素与利奈唑胺治疗脓毒症对C反应蛋白和降钙素原的影响。方法选择2016年1月~2020年12月我院收治的268例脓毒症患者为研究对象,均采用万古霉素或利奈唑胺治疗,运用倾向性评分匹配法矫正组间混杂因素,通过重复测量方差分析法对用药前、用药3 d时的CRP和PCT水平变化情况。结果268例患者中,120例行万古霉素治疗,148例行利奈唑胺治疗;在利奈唑胺组中,用药3 d时的CRP和PCT水平均低于用药前(P<0.05);而在万古霉素组中,用药前后的CRP和PCT水平比较无差异(P>0.05);同时,经倾向性评分匹配对混杂因素进行矫正后,两组患者的治疗有效率和生存率比较差异无统计学意义(P>0.05)。结论临床上在治疗脓毒症患者时,使用利奈唑胺治疗后,能够使CRP和PCT水平降低,起效时间短,但是万古霉素和利奈唑胺在治疗结局方面无明显差异。
Objective To investigate the effect of vancomycin and linazolamine on sepsis on C reactive protein and calcitonogen.Methods 268 patients with sepsis treated in our hospital from January 2016 to December 2020 were treated with vancomycin or lineazolamine.Trend score matching was used to correct the intergroup confounders,and the changes of CRP and PCT before and at 3 d were measured by repeated variance analysis.Results In 120 of the 268 patients in this group,120 underwent vancomycin,and 148 linazolamine,3 d(P<0.05),and no differences between CRP and PCT(P>0.05)in the group(P>0.05).Conclusion CRP and PCT with linazolamine had short effective time,but there was no significant difference between vancomycin and linazolamine.
作者
卢萍
周智恩
姚娟
LU Ping;ZHOU Zhi;EN Yaojuan(Chengdu First People's Hospital,Chengdu Integrated TCM&Western Medicine Hospital,Chengdu 610000,China)
出处
《西部医学》
2022年第5期757-760,共4页
Medical Journal of West China
