摘要
目的分析吲达帕胺联合贝那普利治疗高血压合并心力衰竭的临床效果。方法抽取2019年1月至2021年5月濮阳市安阳地区医院高血压合并心力衰竭患者106例,按随机数字表法分为吲达帕胺组与氢氯噻嗪组,每组53例,氢氯噻嗪组采用氢氯噻嗪联合贝那普利,吲达帕胺组采用吲达帕胺联合贝那普利。对比两组临床效果、血压、心功能、内皮功能、不良反应发生率。结果吲达帕胺组总有效率(90.57%,48/53)较氢氯噻嗪组(75.47%,40/53)高(P<0.05);治疗后,吲达帕胺组舒张压、收缩压较氢氯噻嗪组低(P<0.05);治疗后,吲达帕胺组左心室舒张末期内径较氢氯噻嗪组低,左心室舒张早期与舒张晚期血流峰速比值(E/A)较氢氯噻嗪组高(P<0.05);治疗后,吲达帕胺组内皮素-1、血管紧张素Ⅱ较氢氯噻嗪组低(P<0.05);吲达帕胺组不良反应发生率(5.66%,3/53)较氢氯噻嗪组(20.75%,11/53)低(P<0.05)。结论吲达帕胺联合贝那普利治疗高血压合并心力衰竭患者,可降低血压,改善心功能和血管内皮功能,提高疗效,且不良反应发生率较低。
Objective To analyze the clinical effects of indapamide combined with benazepril in the treatment of hypertension complicated by heart failure.Methods A total of 106 patients with hypertension complicated by heart failure treated in Puyang Anyang Regional Hospital from January 2019 to May 2021 were selected.And they were divided into indapamide group and hydrochlorothiazide group according to the random number table method,with 53 cases in each group.The hydrochlorothiazide group was treated with hydrochlorothiazide combined with benazepril,and the indapamide group was treated with indapamide combined with benazepril.The clinical effects,blood pressure,cardiac function,endothelial function,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the indapamide group(90.57%,48/53)was higher than that of the hydrochlorothiazide group(75.47%,40/53),P<0.05.After treatment,the diastolic blood pressure and systolic blood pressure in the indapamide group were lower than those in the hydrochlorothiazide group(P<0.05).After treatment,the left ventricular end diastolic diameter in the indapamide group was lower than that in the hydrochlorothiazide group,the ratio of peak early to late diastolic filling velocity of the left ventricular inflow in the indapamide group was higher than that in the hydrochlorothiazide group(P<0.05).After treatment,levels of endothelin-1 and angiotensinⅡin the indapamide group were lower than those in the hydrochlorothiazide group(P<0.05).The incidence of adverse reactions in the indapamide group(5.66%,3/53)was lower than that in the hydrochlorothiazide group(20.75%,11/53),P<0.05.Conclusions Indapamide combined with benazepril in the treatment of patients with hypertension complicated by heart failure,can improve heart function and vascular endothelial function,increase curative effect,and has a lower incidence of adverse reactions.
作者
杨睿
葛慧敏
王培
Yang Rui;Ge Huimin;Wang Pei(Department of CardiologyⅡ,Puyang Anyang Regional Hospital,Anyang 455000,China)
出处
《中国实用医刊》
2022年第4期109-112,共4页
Chinese Journal of Practical Medicine
关键词
高血压
心力衰竭
吲达帕胺
贝那普利
血压
心功能
Hypertension
Heart failure
Indapamide
Benazepril
Blood pressure
Heart function
